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Titolo:
Comparison of the effect of perindopril and acebutolol on cerebral hemodynamics in hypertensive patients
Autore:
Pieniazek, W; Dimitrow, PP; Jasinski, T;
Indirizzi:
Jagiellonian Univ, Collegium Medicum, Dept Cardiol 2, PL-31501 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31501 diol 2, PL-31501 Krakow, Poland Jagiellonian Univ, Collegium Medicum, Dept Internal Med 1, Krakow, Poland Jagiellonian Univ Krakow Poland um, Dept Internal Med 1, Krakow, Poland Medicover Dev, Dept Med, Krakow, Poland Medicover Dev Krakow PolandMedicover Dev, Dept Med, Krakow, Poland
Titolo Testata:
CARDIOVASCULAR DRUGS AND THERAPY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 63 - 67
SICI:
0920-3206(2001)15:1<63:COTEOP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; CONVERTING ENZYME-INHIBITION; MILD HYPERTENSION; SYSTEMIC HYPERTENSION; TRANSCRANIAL DOPPLER; PERFUSION-PRESSURE; ARTERY; CIRCULATION; RESISTANCE; RATS;
Keywords:
hypertension; cerebral blood flow; perindopril; acebutolol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Dimitrow, PP Jagiellonian Univ, Collegium Medicum, Dept Cardiol 2, Ul Kopernika 17, PL-31501 Krakow, Poland Jagiellonian Univ Ul Kopernika 17 KrakowPoland PL-31501 and
Citazione:
W. Pieniazek et al., "Comparison of the effect of perindopril and acebutolol on cerebral hemodynamics in hypertensive patients", CARDIO DRUG, 15(1), 2001, pp. 63-67

Abstract

Purpose: The aim of the study was to compare effect of perindopril (4 mg once a day) versus acebutolol (400 mg once a day) on cerebral hemodynamics in hypertensive patients. Methods: Thirty untreated patients with mild-to-mode-rate hypertension were studied. Drug influences on Doppler-derived parameters from the cerebral blood flow (CBF) velocity wave form were evaluated in a randomized, double blind, cross-over, placebo controlled study. The mean CBF velocity, pulsatility index (PI), cerebrovascular resistance and index of CBF were calculated from concomitant transcranial Doppler measurements and systemic blood pressure. Results: Acebutolol and perindopril significantly decreased systolic, diastolic and mean blood pressure in relation to placebo. The mean value of CBFvelocity increased to a comparable level after both drugs (54.9 +/- 9.1 cm/s on placebo vs 62.8 +/- 14.5 cm/s on perindopril p < 0.01 and 61.4 +/- 9.2 cm/s on acebutolol, p < 0.01). Also, the cerebrovascular resistance indexdecreased similarly after both drugs (2.26 +/- 0.35 on placebo vs 1.68 +/-0.42 on perindopril p < 0.01 and 1.7 +/- 0.36 on acebutolol p < 0.01). Thecalculated CBF index increased significantly after each drug (25.23 +/- 7.99 on placebo vs 33.98 +/- 11.23 p < 0.01 on perindopril and 30.90 +/- 8.04on acebutolol p < 0.01). However, perindopril augmented the CBF index moreeffectively than acebutolol (p < 0.05). Conclusions: Among patients with mild-to-moderate hypertension both acebutolol and perindopril beneficially decreased cerebrovascular resistance and increased the CBF index in comparison with placebo. The increase of CBF index was greater after perindopril than acebutolol, which suggests a more significant improvement in cerebral perfusion by perindopril. The non-invasivetranscranial Doppler ultrasonography method of CBF velocity measurement may contribute to choosing optimal antihypertensive therapies and to monitor their effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:30:03