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Titolo:
Understanding the genotoxicity of tamoxifen?
Autore:
Phillips, DH;
Indirizzi:
Inst Canc Res, Haddow Labs, Sutton SM2 5NG, Surrey, England Inst Canc ResSutton Surrey England SM2 5NG tton SM2 5NG, Surrey, England
Titolo Testata:
CARCINOGENESIS
fascicolo: 6, volume: 22, anno: 2001,
pagine: 839 - 849
SICI:
0143-3334(200106)22:6<839:UTGOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER PATIENTS; DNA ADDUCT FORMATION; SPRAGUE-DAWLEY RATS; LAMBDA/LACI TRANSGENIC RATS; HUMAN LYMPHOBLASTOID-CELLS; SURGICAL-ADJUVANT-BREAST; HUMAN LIVER-MICROSOMES; ALPHA-HYDROXYTAMOXIFEN; IN-VIVO; METABOLIC-ACTIVATION;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, DH Inst Canc Res, Haddow Labs, Cotswold Rd, Sutton SM2 5NG, Surrey, England Inst Canc Res Cotswold Rd Sutton Surrey England SM2 5NG gland
Citazione:
D.H. Phillips, "Understanding the genotoxicity of tamoxifen?", CARCINOGENE, 22(6), 2001, pp. 839-849

Abstract

Tamoxifen is an anti-oestrogenic drug widely used for adjuvant therapy of breast cancer. Its use has caused an increased incidence of endometrial cancer and it is also a potent carcinogen in rat liver. Since the demonstration that tamoxifen forms covalent DNA adducts in rat liver, many investigations of its mechanism of carcinogenic action have focused on the examination of human and animal tissues for the presence of tamoxifen-DNA adducts, the identification of their structures and the determination of the metabolic pathways that lead to their formation. This article reviews the current evidence for genotoxic mechanisms for tamoxifen carcinogenicity, and discusses some inconsistencies in the data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:20:07