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Titolo:
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels
Autore:
Guillemette, C; De Vivo, I; Hankinson, SE; Haiman, CA; Spiegelman, D; Housman, DE; Hunter, DJ;
Indirizzi:
Univ Laval, Med Ctr, Oncol & Mol Endocrinol Res Ctr, Fac Pharm, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA MIT, Canc Res Ctr, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Canc Res Ctr, Cambridge, MA 02139 USA Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Harvard Univ, Ctr Canc Prevent, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Ctr Canc Prevent, Boston, MA 02115 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 6, volume: 10, anno: 2001,
pagine: 711 - 714
SICI:
1055-9965(200106)10:6<711:AOGPIU>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE; STEROID TARGET TISSUES; GILBERTS-SYNDROME; CYST FLUID; GLUCURONIDATION; ESTROGENS; PROMOTER; UDP-GLUCURONOSYLTRANSFERASE-1; EXPRESSION; 1A1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Guillemette, C Univ Laval, Med Ctr, Oncol & Mol Endocrinol Res Ctr, Fac Pharm, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Q G1V 4G2, Canada
Citazione:
C. Guillemette et al., "Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels", CANC EPID B, 10(6), 2001, pp. 711-714

Abstract

UDP-glucuronosyltransferases (UGTs) catalyze the detoxification and the elimination of a large number of endogenous and exogenous compounds in the liver and extrahepatic tissues. One of the UGT1A family members, UGT1A1, is involved in estradiol metabolism and, therefore, represents a candidate genein breast carcinogenesis. A common insertion/deletion polymorphism in the TATA-box of the promoter region of UGT1A1 results in decreased initiation of transcription. In a previous study, we found a positive association between the UGT1A1 low-transcriptional alleles and premenopausal breast cancer risk in an African-American population. In the present study, we sought to determine whether the low-transcription UGT1A1 promoter allele, UGT1A1*28 [A(TA)(7)TAA], was associated with increased breast cancer risk among primarily Caucasian women in a nested case-control study within the Nurses' HealthStudy cohort. No significant association between the UGT1A1*28 [A(TA)(7)TAA] allele and breast cancer was observed. Compared with women homozygous for the UGT1A1*1 [A(TA)(6)TAA] allele, the relative risk was 0.80 (confidenceinterval, 0.49-1.29) for women homozygous for the UGT1A1*28 allele, The effect of the UGT1A1 genotype on plasma hormone levels in postmenopausal women not using hormone replacement was also evaluated, and overall, no significant differences in hormone levels by genotypes were observed. When restricted to women who had at least one UGT1A1*28 allele and a body mass index atblood draw of > 27 kg/m(2), particularly in combination with the cytochrome p450c17 alpha genotype, estrone and estradiol levels tended to vary by UGT1A1 genotypes, The results presented do not support a strong association between the UGT1A1 promoter polymorphism and the risk of breast cancer.

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Documento generato il 21/09/20 alle ore 12:44:17