Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: Correlations with diet
Autore:
Poirier, LA; Wise, CK; Delongchamp, RR; Sinha, R;
Indirizzi:
NCI, Environm Epidemiol Branch, Epidemiol & Biostat Program, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 & Biostat Program, NIH, Bethesda, MD 20892 USA US FDA, Natl Ctr Toxicol Res, Div Mol Epidemiol, Jefferson, AR 72079 USA US FDA Jefferson AR USA 72079 Div Mol Epidemiol, Jefferson, AR 72079 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 6, volume: 10, anno: 2001,
pagine: 649 - 655
SICI:
1055-9965(200106)10:6<649:BDOSSA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODERATE FOLATE-DEPLETION; ADENOSYL-L-METHIONINE; CHOLINE-DEVOID DIET; DNA METHYLATION; PLASMA HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE; SEX-DIFFERENCES; RENAL-FAILURE; BREAST-CANCER; COLON-CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Sinha, R NCI, Environm Epidemiol Branch, Epidemiol & Biostat Program, NIH,Execut Plaza S,6130 Execut Blvd, Bethesda, MD 20892 USA NCI Execut Plaza S,6130 Execut Blvd Bethesda MD USA 20892 892 USA
Citazione:
L.A. Poirier et al., "Blood determinations of S-adenosylmethionine, S-adenosylhomocysteine, and homocysteine: Correlations with diet", CANC EPID B, 10(6), 2001, pp. 649-655

Abstract

An increasing number of both clinical and experimental studies have shown an association between deficiencies of the dietary sources of physiologicalmethyl groups and cancer formation. The critical metabolic intermediate ina determination of methylation status is S-adenosylmethionine (SAM), the body's chief physiological methyl donor. The present study examined the erythrocyte levels of SAM and of its demethylated metabolite S-adenosylhomocysteine (SAH) in 66 normal subjects (33 men and 33 women), whose blood had been drawn at days 0, 7 and 14 of an experimental period during which they were fed a fixed diet. The plasma levels of homocysteine (HCys) were also determined in the same individuals at the same time points. In addition, the subjects had completed a food frequency questionnaire (FFQ) describing their usual dietary habits before being placed on the dietary regimen. The blood levels of SAM, SAH, and HCys were compared with the dietary intakes of folate, vitamin B-6, fats, and calories, both prior to using the FFQ and duringthe experimental period. The results indicated that the intraindividual differences were very low, but the interindividual differences were large forthe values of SAM, SAH, SAM: SAH ratios, and HCys. Interestingly, the blood levels of SAM and HCys were higher in men than in women and generally showed the expected correlations with folate intake i.e., positive for SAM andnegative for HCys. The intakes of folate (276 mug/days) and B-6 (1.87 mg/days) during the 2-week experimental period were relatively low compared with the usual intakes of these vitamins (375 and 2.06 mg/day for folate and B-6, respectively) but correlated well with each other during both periods of the study. Surprisingly, both men and women showed a significant rise in erythrocyte SAM:SAH ratios as a function of age. In addition, the combined results from men and women, even adjusted for gender, showed significant correlations between HCys and both weight and body mass index. On the other hand, during the experimental period of the study, blood SAM levels were inversely correlated with the intakes of both fat and calories when the data for both men and women were combined and adjusted for gender. The blood determinations of SAM and related compounds showed a high degree of reproducibility over time and thus appear to provide a practical marker of methylationstatus for the assessment of cancer risk from dietary, environmental, and genetic factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:31:02