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Titolo:
Urinary estrogen metabolites and mammographic parenchymal patterns in postmenopausal women
Autore:
Riza, E; Silva, ID; De Stavola, B; Bradlow, HL; Sepkovic, DW; Linos, D; Linos, A;
Indirizzi:
Univ London London Sch Hyg & Trop Med, Canc & Publ Hlth Unit, Dept Epidemiol & Populat Hlth, London WC1E 7HT, England Univ London London Sch Hyg & Trop Med London England WC1E 7HT T, England Hygeia Diagnost Ctr Athens, Surg Clin 1, GR-14561 Athens, Greece Hygeia Diagnost Ctr Athens Athens Greece GR-14561 R-14561 Athens, Greece Strang Cornell Canc Res Lab, New York, NY 10021 USA Strang Cornell Canc Res Lab New York NY USA 10021 New York, NY 10021 USA Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece Univ Athens Athens Greece Sch Med, Dept Hyg & Epidemiol, Athens, Greece
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 6, volume: 10, anno: 2001,
pagine: 627 - 634
SICI:
1055-9965(200106)10:6<627:UEMAMP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER RISK; HORMONAL REPLACEMENT THERAPY; 2-HYDROXYESTRONE/16-ALPHA-HYDROXYESTRONE RATIO; PREMENOPAUSAL WOMEN; ESTRADIOL; 16-ALPHA-HYDROXYESTRONE; CELLS; DIET; 2-HYDROXYESTRONE; REPRODUCIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Riza, E Univ London London Sch Hyg & Trop Med, Canc & Publ Hlth Unit, DeptEpidemiol & Populat Hlth, Keppel St, London WC1E 7HT, England Univ London London Sch Hyg & Trop Med Keppel St London England WC1E 7HT
Citazione:
E. Riza et al., "Urinary estrogen metabolites and mammographic parenchymal patterns in postmenopausal women", CANC EPID B, 10(6), 2001, pp. 627-634

Abstract

It has been hypothesized that women who metabolize their endogenous estrogens predominantly via 16(alpha)- hydroxylation rather than via 2-hydroxylation and, as a result, have a low ratio of 2-hydroxyestrone (2-OHE1): 16(alpha)-hydroxyestrone (16(alpha)-OHE1) are at an increased risk of breast cancer. Epidemiological evidence in support of this hypothesis is scarce and mostly based on measurements made after the onset of the disease. To gain insight into the role of these metabolites in the etiology of breast cancer, we assessed their relationship with high-density Wolfe mammographic parenchymal patterns (P2/DY), a recognized indicator of risk of this tumor. The study was nested within a large cross-sectional survey on determinants of mammographic patterns carried out in a population-based breast screening program in Northern Greece. Urinary levels of 2-OHE1 and 16(alpha)-OHE1 were measured in a random sample of 70 postmenopausal women with P2/DY mammographic patterns and in a random sample of 70 women with N1 mammographic patterns, individually matched to the P2/DY women on year of birth, years since menopause and date of urine collection. Women with a P2/DY pattern had, on average, 58% higher levels of 2-OHE1 (P = 0.002) and 15% higher levels of 16(alpha)- OHE1 (P = 0.37) than those with an N1 pattern. The ratio of 2-OHE1:16(alpha)-OHE1 was 35% higher (P = 0.005) in women with a P2/DY pattern. Womenin the highest one-third of this ratio were six times more likely to have a P2/DY pattern than those in the lowest one-third after adjusting for potential confounders (prevalence odds ratio, 6.2; 95% CI, 1.7-22.9; test for linear trend, P = 0.002). These findings seem to suggest that a high, ratherthan a low, 2-OHE1:16(alpha)-OHE1 ratio may be associated with an increasein breast cancer risk at postmenopausal ages, unless the pathway through which estrogen metabolites may affect breast cancer risk is unrelated to mammographic parenchymal patterns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:46:46