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Titolo:
Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility
Autore:
Whyatt, RM; Jedrychowski, W; Hemminki, K; Santella, RM; Tsai, WY; Yang, K; Perera, FP;
Indirizzi:
Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY10032 USA Columbia Univ New York NY USA 10032 ironm Hlth Sci, New York, NY10032 USA Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USAColumbia Univ New York NY USA 10032 Dept Biostat, New York, NY 10032 USA Jagiellonian Univ, Coll Med, PL-31014 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31014 ll Med, PL-31014 Krakow, Poland Karolinska Inst, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 Biosci, S-14157 Huddinge, Sweden
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 6, volume: 10, anno: 2001,
pagine: 581 - 588
SICI:
1055-9965(200106)10:6<581:BOPAHD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL TOBACCO-SMOKE; LUNG-CANCER; COTININE LEVELS; PREGNANT-WOMEN; MOLECULAR EPIDEMIOLOGY; MICRONUCLEUS FORMATION; GESTATION STAGE; AMNIOTIC-FLUID; HUMAN PLACENTA; ADDUCTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Whyatt, RM Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, 60 Haven Ave,B-1, New York, NY 10032 USA Columbia Univ 60 Haven Ave,B-1 New York NY USA 10032 10032 USA
Citazione:
R.M. Whyatt et al., "Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility", CANC EPID B, 10(6), 2001, pp. 581-588

Abstract

Human and experimental evidence indicates that the developing fetus may bemore susceptible than the adult to the effects of certain carcinogens, including some polycyclic aromatic hydrocarbons (PAHs), Factors that can modulate susceptibility include proliferation rates, detoxification capabilities, and DNA repair capacity. Biomarkers can facilitate quantification of age-related susceptibility among human populations. In this study, we report onthree biomarkers measured in paired blood samples collected at birth from 160 Polish mothers and newborns: 70 pairs from Krakow (a city with high airpollution including PAHs) and 90 pairs from Limanowa (an area with lower ambient pollution but greater indoor coal use). Biomarkers were: WBC aromatic-DNA adducts by P-32-postlabeling and PAH-DNA adducts by ELISA (as indicators of DNA damage from PAHs and other aromatics) and plasma cotinine (as aninternal dosimeter of cigarette smoke). Correlations were assessed by Spearman's rank test, and differences in biomarker levels were assessed by the Wilcoxon signed-ranks test. A significant correlation between paired newborn/maternal samples was seen for aromatic-DNA adduct levels (r 0.3; P < 0.001) and plasma cotinine (r = 0.8; P < 0.001) but not PAH-DNA adduct levels (r = 0.14; P = 0.13). Among the total cohort, levels of the three biomarkerswere higher in newborn samples compared with paired maternal samples. The difference was significant for aromatic-DNA adduct levels (16.6 +/- 12.5 versus 14.21 +/- 15.4/10(8) nucleotides; P = 0.002) and plasma cotinine (14.2+/- 35.5 versus 8.3 +/- 24.5 ng/ml; P < 0.001) but not for PAH-DNA adduct levels (7.9 +/- 9.9 versus 5.9 +/- 8.2/ 10(8) nucleotides; P = 0.13). When analyses were restricted to the 80 mother/newborn pairs from whom the bloodsample was drawn concurrently (within 1 h of each other), levels of all ofthe three biomarkers were significantly higher in the newborn compared with paired maternal blood samples (P < 0.05). Results suggest reduced detoxification capabilities and increased susceptibility of the fetus to DNA damage, especially in light of experimental evidence that transplacental exposures to PAHs are 10-fold lower than paired maternal exposures. The results have implications for risk assessment, which currently does not adequately account for sensitive subsets of the population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:59:26