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Titolo:
Genetic determinants of serum prostate-specific antigen levels in healthy men from a multiethnic cohort
Autore:
Xue, WM; Coetzee, GA; Ross, RK; Irvine, R; Kolonel, L; Henderson, BE; Ingles, SA;
Indirizzi:
Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Sch Med, Los Angeles, CA 90033 USA Univ So Calif, Keck Sch Med, Dept Urol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 pt Urol, Los Angeles, CA 90033 USA Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA Univ Hawaii Honolulu HIUSA 96813 i, Canc Res Ctr, Honolulu, HI 96813 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 6, volume: 10, anno: 2001,
pagine: 575 - 579
SICI:
1055-9965(200106)10:6<575:GDOSPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN RECEPTOR GENE; CANCER RISK; REPEATS; LENGTH; CAG; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ingles, SA Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Keck Sch Med, 1441 Eastlake Ave,MS44,Room 6419, Los Angeles, CA 90033 USA Univ So Calif 1441 Eastlake Ave,MS44,Room 6419 Los Angeles CA USA 90033
Citazione:
W.M. Xue et al., "Genetic determinants of serum prostate-specific antigen levels in healthy men from a multiethnic cohort", CANC EPID B, 10(6), 2001, pp. 575-579

Abstract

We recently reported an association between prostate cancer risk and polymorphisms in the prostate-specific antigen (PSA) and androgen receptor (AR) genes. The purpose of this study is to test whether these two polymorphisms, AR CAG and PSA ARE1, influence serum PSA levels in healthy men. Serum PSAand the two genotypes were assayed for 420 healthy men from a multiethnic cohort, and regression models were fit to estimate the effects of AR CAG genotype and PSA ARE1 genotype on serum PSA levels. Predicted serum PSA decreased 3.5% with each additional AR CAG repeat decile (P = 0.01). Serum PSA was also associated with PSA ARE1 genotype, with PSA levels higher among menwith the PSA AA genotype compared with men with the AG or GG genotypes (P = 0.02). The relationship between serum PSA level and AR CAG length differed according to PSA genotype (P = 0.049): for genotype GG, the slope was notsignificantly different from zero (P = 0.74); for genotype AG, serum PSA increased 4.5% with each decrease of one CAG repeat decile (P = 0.03); for genotype AA, serum PSA increased 7% with each decrease of one CAG repeat decile (P = 0.02). These results indicate that in healthy men, genetic variants in the PSA and AR genes contribute to variation in serum PSA levels. Men with the IPSA AA genotype and short AR CAG alleles have, on average, higherserum PSA levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:10:17