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Titolo:
Elevated serum homocysteine levels and increased risk of invasive cervicalcancer in US women
Autore:
Weinstein, SJ; Ziegler, RG; Selhub, J; Fears, TR; Strickler, HD; Brinton, LA; Hamman, RF; Levine, RS; Mallin, K; Stolley, PD;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA NCI BethesdaMD USA 20892 Epidemiol & Genet, NIH, Bethesda, MD 20892 USA Tufts Univ, Human Nutr Res Ctr Aging, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 n Nutr Res Ctr Aging, Boston, MA 02111 USA Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10467 USAAlbert Einstein Coll Med Bronx NY USA 10467 cial Med, Bronx, NY 10467 USA Univ Colorado, Sch Med, Dept Prevent Med & Biometr, Denver, CO USA Univ Colorado Denver CO USA , Dept Prevent Med & Biometr, Denver, CO USA Meharry Med Coll, Sch Med Occupat & Prevent Med, Nashville, TN 37208 USA Meharry Med Coll Nashville TN USA 37208 vent Med, Nashville, TN 37208 USA Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA Univ Illinois Chicago IL USA h, Div Epidemiol & Biostat, Chicago, IL USA Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Prevent Med, Baltimore, MD 21201 USA
Titolo Testata:
CANCER CAUSES & CONTROL
fascicolo: 4, volume: 12, anno: 2001,
pagine: 317 - 324
SICI:
0957-5243(2001)12:4<317:ESHLAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNITED-STATES; FOLIC-ACID; HUMAN PAPILLOMAVIRUS; INTRAEPITHELIAL NEOPLASIA; FOLATE-DEFICIENCY; INTEGRATION SITES; VITAMIN STATUS; PLASMA FOLATE; FRAGILE SITES; WHITE WOMEN;
Keywords:
cervix neoplasms; homocysteine; nutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, RG NCI, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd,MSC 7246, Bethesda,MD 20892 USA NCI 6120 Execut Blvd,MSC 7246 Bethesda MD USA 20892 20892 USA
Citazione:
S.J. Weinstein et al., "Elevated serum homocysteine levels and increased risk of invasive cervicalcancer in US women", CANC CAUSE, 12(4), 2001, pp. 317-324

Abstract

Objectives: To explore the relationship between serum homocysteine, a sensitive biomarker for folate inadequacy and problems in one-carbon metabolism, and invasive cervical cancer. Methods: A large case-control study was conducted in five US areas with upto two community controls, obtained by random-digit dialing, individually matched to each case. Cervical cancer risk factors were assessed through at-home interview. Blood was drawn at least 6 months after completion of cancer treatment from 51% and 68% of interviewed cases and controls. Serum homocysteine was measured by high-performance liquid chromatography, and exposure to human papillomavirus (HPV) type 16, the most prevalent oncogenic type, was assessed using an enzyme-linked immunosorbent assay. Cases with advanced cancer and/or receiving chemotherapy were excluded, leaving 183 cases and 540 controls. Results: Invasive cervical cancer risk was substantially elevated for women in the upper three homocysteine quartiles (>6.31 mu mol/L); multivariate-adjusted odds ratios ranged from 2.4 to 3.2 (all 95% CIs excluded 1.0). A trend was apparent and significant (p = 0.01). When cases were compared withHPV-16 seropositive controls only, odds ratios were comparable. Conclusions: Serum homocysteine was strongly and significantly predictive of invasive cervical cancer risk. This association could reflect folate, B-12 and/or B-6 inadequacy, or genetic polymorphisms affecting one-carbon metabolism.

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Documento generato il 05/12/20 alle ore 13:58:21