Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia
Autore:
Lawrie, SM; Byrne, M; Miller, P; Hodges, A; Clafferty, RA; Owens, DGC; Johnstone, EC;
Indirizzi:
Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF idlothian, Scotland
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 178, anno: 2001,
pagine: 524 - 530
SICI:
0007-1250(200106)178:<524:NIATDO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINOR PHYSICAL ANOMALIES; NEUROLOGICAL SOFT SIGNS; SIBLINGS; ABNORMALITIES; DISORDERS; BIPOLAR; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lawrie, SM Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF Scotland
Citazione:
S.M. Lawrie et al., "Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia", BR J PSYCHI, 178, 2001, pp. 524-530

Abstract

Background Neurological 'soft signs' and minor physical anomalies (MPAs) are reported to be more frequent in patients with schizophrenia than in controls. Aims To determine whether these disturbances are genetically mediated, andwhether they are central to the genesis of symptoms or epiphenomena,Method We obtained ratings in 152 individuals who were antipsychotic drug-free and at high risk. some of whom had experienced psychotic symptoms, as well as 30 first-episode patients and 35 healthy subjects. Results MPAs and Neurological Evaluation Scale (NES) 'sensory integration abnormalities' were more frequent in high-risk subjects than in healthy controls. but there were no reliable differences between high-risk subjects with and without psychotic Symptoms. MPAs were most frequent in high-risk subjects with least genetic liability and NES scores showed no genetic associations. Conclusions The lack of associations with psychotic symptoms and genetic liability to schizophrenia suggests that soft signs and physical anomalies are nonspecific markers of developmental deviance that are not mediated by the gene(s) for schizophrenia. Declaration of interest None. Funding from the Medical Research Council ofGreat Britain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:17:47