Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Human papillomavirus infection in Netherton's syndrome
Autore:
Weber, F; Fuchs, PG; Pfister, HJ; Hintner, H; Fritsch, P; Hoepfl, R;
Indirizzi:
Innsbruck Univ, Dept Dermatol & Venerol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 nerol, A-6020 Innsbruck, Austria Univ Cologne, Inst Virol, D-5000 Cologne 41, Germany Univ Cologne Cologne Germany 41 , Inst Virol, D-5000 Cologne 41, Germany Gen Hosp Salzburg, Dept Dermatol, Salzburg, Austria Gen Hosp Salzburg Salzburg Austria rg, Dept Dermatol, Salzburg, Austria
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 5, volume: 144, anno: 2001,
pagine: 1044 - 1049
SICI:
0007-0963(200105)144:5<1044:HPIINS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS-LIKE PARTICLES; RENAL-TRANSPLANT RECIPIENTS; EPIDERMODYSPLASIA-VERRUCIFORMIS; SKIN-LESIONS; SERUM IGG; ANTIBODIES; CANCERS; HPV; PREVALENCE; TYPE-11;
Keywords:
human papillomavirus; immunodeficiency; Netherton's syndrome; non-melanoma skin cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Weber, F Innsbruck Univ, Dept Dermatol & Venerol, Anichstr 35, A-6020 Innsbruck, Austria Innsbruck Univ Anichstr 35 Innsbruck Austria A-6020 uck, Austria
Citazione:
F. Weber et al., "Human papillomavirus infection in Netherton's syndrome", BR J DERM, 144(5), 2001, pp. 1044-1049

Abstract

Background Netherton's syndrome (NS) is a hereditary disorder with dermatological signs (e.g. ichthyosis) and a complex immunological dysfunction. Inimmunodeficient individuals human papillomavirus (HPV) types are associated with carcinomas on non-mucosal sites. Objectives To study the presence of HPV infection in different skin lesions of three male NS patients and to investigate a possible association between HPV and malignancies in NS. Methods Patient 1 had extraordinary widespread multiple skin carcinomas onsunlight-exposed areas, as well as common viral warts. Patient 2 showed disseminated viral plane warts that resolved spontaneously, and patient 3 wasfree of skin lesions suspicious for HPV infection; only pseudoepitheliomatous wart-like lesions as a symptom of ichthyosis were apparent. We performed nested polymerase chain reaction analysis of DNA from benign and malignant skin lesions and HPV-8 serology in these three patients. Results Antibodies to HPV-8 were not detectable in our patients; however, seven of 22 (31%) biopsies of the three NS patients were positive for HPV DNA. Epidermodysplasia verruciformis (EV) -associated HPV types and normal cutaneous types (HPV-2, HPV-28) were detected. Interestingly, only the patient with cutaneous carcinomas harboured, preferentially in malignant lesions, EV-HPV types (HPV-19, 23, 38 and HPV-RTRX9, closely related to EV-HPVs), whereas plane warts of patient 2 were positive for HPV-28. The pseudoepitheliomatous skin lesions were HPV-DNA negative in all investigated probes. Conclusions These data in NS patients further confirm an association of EV-HPVs with non-melanoma skin cancer (NMSC) and suggest a possible carcinogenic role similar to that assumed for NMSC in transplant recipients. A complex immunological disorder facilitating EV-HPV infection, negative HPV serology and photochemotherapy may all have contributed to the unusual occurrence of multiple cancers in one of our NS patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:42:41