Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The clinical transition between pemphigus foliaceus and pemphigus vulgariscorrelates well with the changes in autoantibody profile assessed by an enzyme-linked immunosorbent assay
Autore:
Komai, A; Amagai, M; Ishii, K; Nishikawa, T; Chorzelski, T; Matsuo, I; Hashimoto, T;
Indirizzi:
Kurume Univ, Sch Med, Dept Dermatol, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011 Dept Dermatol, Fukuoka 8300011, Japan Keio Univ, Sch Med, Dept Dermatol, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Sch Med, Dept Dermatol, Tokyo, Japan Warsaw Sch Med, Dept Dermatol, Warsaw, Poland Warsaw Sch Med Warsaw Poland saw Sch Med, Dept Dermatol, Warsaw, Poland Teikyo Univ, Sch Med, Ichihara Hosp, Dept Dermatol, Chiba, Japan Teikyo Univ Chiba Japan Med, Ichihara Hosp, Dept Dermatol, Chiba, Japan
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 6, volume: 144, anno: 2001,
pagine: 1177 - 1182
SICI:
0007-0963(2001)144:6<1177:TCTBPF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATHOGENIC AUTOANTIBODIES; DESMOSOMAL GLYCOPROTEIN; ADHESION MOLECULES; CELL-ADHESION; SKIN DISEASES; DESMOGLEIN-1; IMMUNOBLOT; BACULOVIRUS; ANTIBODIES; CADHERINS;
Keywords:
desmoglein; enzyme-linked immunosorbent assay; pemphigus foliaceus; pemphigus vulgaris;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, T Kurume Univ, Sch Med, Dept Dermatol, 67 Asahimachi, Fukuoka 8300011, Japan Kurume Univ 67 Asahimachi Fukuoka Japan 8300011 00011, Japan
Citazione:
A. Komai et al., "The clinical transition between pemphigus foliaceus and pemphigus vulgariscorrelates well with the changes in autoantibody profile assessed by an enzyme-linked immunosorbent assay", BR J DERM, 144(6), 2001, pp. 1177-1182

Abstract

Background There are a number of reports of pemphigus with clinical shifting between pemphigus foliaceus (PF) and pemphigus vulgaris (PV). On the other hand, a novel enzyme-linked immunosorbent assay (ELISA) against recombinant baculoproteins of desmoglein 1 (Dsg1) (PF antigen) and Dsg3 (PV antigen) has been established and found to be extremely sensitive and specific. Objectives To characterize the change in the antibody profiles in a seriesof pemphigus cases with mixed features of PF and PV by various methods, including the novel ELISA. Patients/methods Sera were obtained from eight cases undergoing a shift between PF and PV and three cases of coexistent PF and PV. The autoantigens were analysed by ELISA, as well as by immunofluorescence using normal human skin sections and immunoblotting using normal human epidermal extracts. Results The results of the ELISA, immunofluorescence and immunoblotting studies showed that the transition between PF and PV correlates well with thechanges of autoantibodies against either Dsg1 or Dsg3. Conclusions The clinical phenotype at each stage is defined by the anti-Dsg antibody profile in the serum of these pemphigus patients showing mixed features of PF and PV. In addition, ELISA using recombinant baculoproteins was particularly useful in distinguishing PF and PV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:49:00