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Titolo:
Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation
Autore:
Peluso, J; Gaveriaux-Ruff, C; Matthes, HWD; Filliol, D; Kieffer, BL;
Indirizzi:
CNRS, UPR9050, ESBS, F-67400 Illkirch, France CNRS Illkirch France F-67400 RS, UPR9050, ESBS, F-67400 Illkirch, France Fac Pharm, Illkirch, France Fac Pharm Illkirch FranceFac Pharm, Illkirch, France
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 54, anno: 2001,
pagine: 655 - 660
SICI:
0361-9230(200104)54:6<655:OFBTFC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-S BINDING; ACTIVATED PROTEIN-KINASE; HAMSTER OVARY CELLS; OPIOID RECEPTOR; NOCICEPTIN/ORPHANIN FQ; MICE; IDENTIFICATION; MODULATION; EXPRESSION; AGONIST;
Keywords:
orphanin FQ/nociceptin; ORL-1 receptor; immune cells; proliferation; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gaveriaux-Ruff, C CNRS, UPR9050, ESBS, Bld S Brant, F-67400 Illkirch, France CNRS Bld S Brant Illkirch France F-67400 lkirch, France
Citazione:
J. Peluso et al., "Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation", BRAIN RES B, 54(6), 2001, pp. 655-660

Abstract

Orphanin FQ/nociceptin (OFQ/N) has been shown to modulate nociception, responses to stress and anxiety. We investigated OFQ/N function in human immune cells. We find that monocytic U937, T Iymphocytic GEM, and MOLT-4 cell lines express OFQ/N binding sites at levels comparable to that of human SH-SY5Y neuroblastoma cells. We show that OFQ/N receptors are functionally coupled to G proteins in these cells. Finally OFQ/N decreases proliferation of phytohemagglutininstimulated peripheral blood mononuclear cells in vitro at doses ranging from 10(-13) to 10(-8) M. Thus, our data suggest that OFQ/N and OFQ/N receptor may act as an immunomodulatory system. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:30:49