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Titolo:
Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via dopamine receptors
Autore:
Zackheim, JA; Abercrombie, ED;
Indirizzi:
Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA RutgersState Univ Newark NJ USA 07102 hav Neurosci, Newark, NJ 07102 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 54, anno: 2001,
pagine: 603 - 607
SICI:
0361-9230(200104)54:6<603:DSDEAI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; SUBSTANTIA-NIGRA; BRAIN DIALYSIS; D-2 RECEPTORS; RAT STRIATUM; MOVING RATS; RELEASE; MICRODIALYSIS; ANTAGONISTS; INHIBITION;
Keywords:
(+/-)-SKF 38393; (+/-)-SKF 82958; dopamine; striatum; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Zackheim, JA Rutgers State Univ, Ctr Mol & Behav Neurosci, 197 Univ Ave, Newark, NJ 07102 USA Rutgers State Univ 197 Univ Ave Newark NJ USA 07102 07102 USA
Citazione:
J.A. Zackheim e E.D. Abercrombie, "Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via dopamine receptors", BRAIN RES B, 54(6), 2001, pp. 603-607

Abstract

Previous pharmacological studies have reported that striatal dopamine efflux is negatively modulated not only by presynaptic D2 dopamine autoreceptors but also by striatal D1 dopamine receptors. The present experiments employed in vivo microdialysis to further examine the ability of widely used benzazepine-class D1 agonists to modulate striatal dopamine efflux. In the present study, both the partial D1 agonist (+/-)-SKF 38393 (10 muM) and the full D1 agonist (+/-)-SKF 82958 (10 and 100 muM) significantly reduced striatal dopamine efflux during intrastriatal application. Intrastriatal application of the less active enantiomer, S(-)-SKF 38393 (10 muM) did not decreasestriatal dopamine suggesting a selective receptor-mediated mode of action of (+/-)-SKF 38393, Additional experiments were conducted with the full D1 agonist (+/-)-SKF 82958 in order to characterize the receptor(s) mediating the observed decrease in dopamine efflux, Neither local application of the D1 antagonist R(+)-SCH 23390 (100 muM) nor local application of the selective D2 antagonist raclopride (5 muM) blocked the ability of (+)-SKF 82958 (10 muM) to decrease striatal dopamine efflux. However, intrastriatal application of the less selective D2 antagonist haloperidol (1 muM) did prevent the decrease in striatal dopamine efflux observed during intrastriatal (+/-)-SKF 82958 application. The present data suggest that the ability of intrastriatally applied benzazepine-class D1 agonists to decrease striatal dopamine efflux is receptor-mediated, but this action apparently is not mediated at D1 or D2 receptors, There is therefore no indication for an intrastriatalpopulation of D1 receptors capable of modulating dopamine efflux, (C) 2001Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:56:51