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Titolo:
Recovery of brain function during induced cerebral hypoperfusion
Autore:
Marshall, RS; Lazar, RM; Pile-Spellman, J; Young, WL; Duong, DH; Joshi, S; Ostapkovich, N;
Indirizzi:
Columbia Univ, New York Presbyterian Med Ctr, Dept Neurol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Neurol, New York, NY 10032 USA Columbia Univ, New York Presbyterian Med Ctr, Dept Radiol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Dept Radiol, New York, NY 10032 USA Columbia Univ, New York Presbyterian Med Ctr, Dept Neurol Surg, New York, NY 10032 USA Columbia Univ New York NY USA 10032 t Neurol Surg, New York, NY 10032 USA Columbia Univ, New York Presbyterian Med Ctr, Dept Anesthesiol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 t Anesthesiol, New York, NY 10032 USA Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA are, San Francisco, CA USA Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA urg, San Francisco, CA USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA Univ Calif San Francisco San Francisco CA USA rol, San Francisco, CA USA
Titolo Testata:
BRAIN
, volume: 124, anno: 2001,
parte:, 6
pagine: 1208 - 1217
SICI:
0006-8950(200106)124:<1208:ROBFDI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNAL CAROTID-ARTERY; POSITRON-EMISSION-TOMOGRAPHY; BLOOD-FLOW MEASUREMENTS; BALLOON TEST OCCLUSION; ACUTE STROKE; ISCHEMIA; THRESHOLDS; RISK; ENDARTERECTOMY; HEMODYNAMICS;
Keywords:
cerebral blood flow; carotid artery occlusion; stroke; recovery; sustained attention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Marshall, RS Columbia Univ, New York Presbyterian Med Ctr, Dept Neurol, 710 W 168th St,New York, NY 10032 USA Columbia Univ 710 W 168th St New York NY USA 10032 10032 USA
Citazione:
R.S. Marshall et al., "Recovery of brain function during induced cerebral hypoperfusion", BRAIN, 124, 2001, pp. 1208-1217

Abstract

We used the setting of clinically indicated internal carotid artery balloon test occlusions in 44 patients with inoperable carotid cavernous aneurysms or head and neck tumours to examine real-time changes in higher cerebral function that correlate with specific levels of cerebral blood flow. By making detailed haemodynamic and neurobehavioural measurements during the 30 min the carotid artery was occluded, we were able to quantify higher cerebral function patterns in relation to absolute cerebral blood flow (CBF) levels. We found that once the carotid artery was occluded, patients whose CBF averaged 47 ml/100g/min (no different from baseline) maintained consistent performance on a sustained attention task; those whose CBF dropped to an average 37 ml/100g/min had a reversible deterioration of sustained attention, and those whose CBF fell to 27 ml/100 g/min had impaired sustained attention that persisted until the carotid occlusion was reversed. The relevance ofthese results to the pathological state of clinical stroke is discussed with respect to the haemodynamic and physiological mechanisms that may determine how brain function is lost and regained in the setting of acute cerebral hypoperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:22:40