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Titolo:
Are dietary influences on the risk of prostate cancer mediated through theinsulin-like growth factor system?
Autore:
Mucci, LA; Tamimi, R; Lagiou, P; Trichopoulou, A; Benetou, V; Spanos, E; Trichopoulos, D;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece Univ Athens Athens Greece Sch Med, Dept Hyg & Epidemiol, Athens, Greece Biomed Int Diagnost Ctr, Athens, Greece Biomed Int Diagnost Ctr Athens Greece Int Diagnost Ctr, Athens, Greece
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 9, volume: 87, anno: 2001,
pagine: 814 - 820
SICI:
1464-4096(200106)87:9<814:ADIOTR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BINDING PROTEIN-2; FACTOR-I; CIRCULATING INSULIN-LIKE-GROWTH-FACTOR-1; ELDERLY MEN; CELL-LINES; IGF-I; GREECE; POPULATION; CARCINOMA; SELENIUM;
Keywords:
IGF-1; dietary factors; prostate cancer; risk; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Trichopoulos, D Harvard Univ, Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA Harvard Univ 677 Huntington Ave Boston MA USA 02115 15 USA
Citazione:
L.A. Mucci et al., "Are dietary influences on the risk of prostate cancer mediated through theinsulin-like growth factor system?", BJU INT, 87(9), 2001, pp. 814-820

Abstract

Objectives To investigate whether dietary factors that appear to affect the risk of prostate cancer may be similarly associated with serum levels of insulin-like growth factor 1 (IGF-1). Patients and methods In the context of a case-control study, 112 men were admitted to three teaching hospitals in Athens, Greece, for disorders otherthan cancer. Sociodemographic data and detailed histories of smelting, alcohol and coffee consumption were recorded. A validated food-frequency questionnaire was administered by an interviewer and serological measurements ofIGF-1 and its binding protein-3 conducted. Results IGF-1 declined significantly by almost 25% among men aged > 75 years and there was a small reduction in IGF-1 levels with increased alcohol intake, with a mean (95% confidence interval, CI) change of -1.6 (-2.2 to -0.9)% for an increment of one drink per day, There was no evidence for an effect of either smelting or coffee consumption on IGF-1 level. Among foods, the consumption of cooked tomatoes was substantially and significantly inversely associated with IGF-1 levels, with a mean (95% CI) change of -31.5 (-43.1 to -7.9)% for an increment of one serving per day. Conclusions The strongest known dietary risk factor for prostate cancer (lycopene deficit, as reflected in a reduced intake of cooked tomatoes) and an important endocrine factor in the aetiology of this disease (IGF-1) seem to be related in a way that suggests that at least one, and perhaps more, exogenous factors in the development of prostate cancer may be mediated through the IGF-1 system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:20:39