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Titolo:
Rapid degradation of the silkworm diapause hormone by trypsin and its suppression by VAP-map, a synthetic analog of the cuticular peptide of silkworm, Bm ACP-6.7 (VAP-Peptide)
Autore:
Baba, H; Katsuzaki, H; Komiya, T; Yamashita, O; Imai, K;
Indirizzi:
Mie Univ, Fac Bioresources, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 Fac Bioresources, Tsu, Mie 5148507, Japan Nagoya Univ, Grad Sch Bioagr Sci, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 Sci, Nagoya, Aichi 4648601, Japan
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 5, volume: 65, anno: 2001,
pagine: 1033 - 1037
SICI:
0916-8451(200105)65:5<1033:RDOTSD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOMBYX-MORI; BIOLOGICAL-ACTIVITY; NEUROPEPTIDES; IDENTIFICATION; EXPRESSION; SEQUENCE;
Keywords:
diapause hormone; tryptic digestion; cuticular peptide; diapause hormone-synergist interaction; suppressed enzymic degradation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Imai, K Mie Univ, Fac Bioresources, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 resources, Tsu, Mie 5148507, Japan
Citazione:
H. Baba et al., "Rapid degradation of the silkworm diapause hormone by trypsin and its suppression by VAP-map, a synthetic analog of the cuticular peptide of silkworm, Bm ACP-6.7 (VAP-Peptide)", BIOS BIOT B, 65(5), 2001, pp. 1033-1037

Abstract

Very fast tryptic degradation of the silkworm diapause hormone was found and the degradation pathway was analyzed by moderating the reaction conditions. It proceeded via cleavage at Arg(23) and finally at Arg(15) of DH. As the C-terminal structure of DH was essential for exhibiting bioactivity, thefirst cleavage caused rapid inactivation of the hormone. This tryptic digestion was strongly suppressed by adding VAP-map, a synthetic analog of the cuticular peptide of silkmoths, Bm ACP-6.7 (VAP-peptide), which is a natural synergist of DH. VAP-map suppressed the enzymic reaction by interacting with the substrate, but not with the enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:03:40