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Titolo:
New approaches to treatment in systemic vasculitis: biological therapies
Autore:
Levine, SM; Stone, JH;
Indirizzi:
Johns Hopkins Vasculitis Ctr, Div Rheumatol, Baltimore, MD 21205 USA JohnsHopkins Vasculitis Ctr Baltimore MD USA 21205 ltimore, MD 21205 USA Johns Hopkins Vasculitis Ctr, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Vasculitis Ctr Baltimore MD USA 21205 ltimore, MD 21205 USA
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 315 - 333
SICI:
1521-6942(200106)15:2<315:NATTIS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GIANT-CELL ARTERITIS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; CYTOKINE PRODUCTION PROFILE; INTERFERON-ALPHA TREATMENT; HEPATITIS-C VIRUS; RHEUMATOID-ARTHRITIS; BEHCETS-DISEASE; ENDOTHELIAL-CELLS; WEGENERS-GRANULOMATOSIS; POLYMYALGIA-RHEUMATICA;
Keywords:
vasculitis; biological; tumour necrosis factor; interleukin-10; interleukin-12; interleukin-1; cytotoxic T-cell antigen 4 (CTLA-4); interferon-alpha; interferon-gamma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Levine, SM Johns Hopkins Vasculitis Ctr, Div Rheumatol, 1830 E Monument St,Suite 7500, Baltimore, MD 21205 USA Johns Hopkins Vasculitis Ctr 1830 E Monument St,Suite 7500 Baltimore MD USA 21205
Citazione:
S.M. Levine e J.H. Stone, "New approaches to treatment in systemic vasculitis: biological therapies", BEST PR R C, 15(2), 2001, pp. 315-333

Abstract

Although the effectiveness of biological agents in systemic vasculitis is unproven, their introduction heralds a new era of vasculitis treatment. These agents offer the promise of targeted immunotherapies; the possibility ofgreater efficacy (and fewer side-effects) than conventional vasculitis treatments; and the potential to provide novel insights into the pathophysiology of these diseases - insights that may be gained only by using these agents in humans. Challenges to the investigation of these therapies in the systemic vasculitides exist, but important basic and clinical investigations are already in progress. We review the major issues facing the investigationof biological agents in vasculitis; examine the rationale for believing that biological strategies in vasculitis will be efficacious; identify several candidate targets for biological approaches; and discuss the results to date of early studies. The potential biological targets discussed include cytokines such as tumour necrosis factor; interleukins-1, -6, and -12; interferon-gamma; the co-stimulatory molecules B7-1 and B7-2; and others.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:07:11