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Titolo:
New therapeutic aspects: haemopoietic stem cell transplantation
Autore:
Bacon, PA; Carruthers, D;
Indirizzi:
Univ Birmingham, Sch Med, Dept Rheumatol, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England City Hosp NHS Trust, Dept Rheumatol, Birmingham, W Midlands, England City Hosp NHS Trust Birmingham W Midlands England m, W Midlands, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 299 - 313
SICI:
1521-6942(200106)15:2<299:NTAHSC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; SYSTEMIC NECROTIZING VASCULITIS; HIGH-DOSE CYCLOPHOSPHAMIDE; CHURG-STRAUSS-SYNDROME; AUTOIMMUNE-DISEASE; WEGENERS GRANULOMATOSIS; PULSE CYCLOPHOSPHAMIDE; POLYARTERITIS-NODOSA; RANDOMIZED TRIAL; EUROPEAN-GROUP;
Keywords:
vasculitis; stem cell transplantation; high dose immunosuppression; stem cell mobilisation; condition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Bacon, PA Univ Birmingham, Sch Med, Dept Rheumatol, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT , England
Citazione:
P.A. Bacon e D. Carruthers, "New therapeutic aspects: haemopoietic stem cell transplantation", BEST PR R C, 15(2), 2001, pp. 299-313

Abstract

Primary systemic vasculitis responds well to intensive immunosuppression, particularly with cyclophosphomide. Use of the latter is restricted by side-effects, particularly in relapsing disease. Techniques which allow more complete immunosuppression have an obvious attraction in autoimmune disease. They are particularly suitable for vasculitis which can go into long-lasting remission even with standard therapy in many cases. The conditioning usedfor stem cell transplantation allows more complete deletion of auto aggressive T-cell clones, with subsequently haemopoietic rescue by previously harvested stem cell precursors. The procedure also has immune potentiating effects, perhaps by promoting peripheral suppressor mechanisms. These may be important even though immune ablation is not achieved. With rigorous patientselection, experience with this technique in vasculitis may be broadened.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:42:37