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Titolo:
Tissue targeting and disease patterns in systemic vasculitis
Autore:
Cid, MC; Vilardell, C;
Indirizzi:
Univ Barcelona, Hosp Clin Barcelona, Dept Internal Med,Vasculitis Res Unit, Inst Invest Biomed August Pi I Sunyer,IDIBAPS, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 IDIBAPS, E-08036 Barcelona, Spain
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 259 - 279
SICI:
1521-6942(200106)15:2<259:TTADPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GIANT-CELL ARTERITIS; ADHESION MOLECULE EXPRESSION; IMMUNOLOGICAL ACTIVATION MARKERS; HUMAN-IMMUNODEFICIENCY-VIRUS; SECONDARY LYMPHOID ORGANS; HIGH ENDOTHELIAL VENULES; CHURG-STRAUSS-SYNDROME; MEMORY T-CELLS; POLYARTERITIS-NODOSA; TEMPORAL ARTERITIS;
Keywords:
vasculitis; tissue targeting; adhesion molecules; chemokines; disease phenotypes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Cid, MC Univ Barcelona, Hosp Clin Barcelona, Dept Internal Med,Vasculitis Res Unit, Inst Invest Biomed August Pi I Sunyer,IDIBAPS, E-08036 Barcelona,Spain Univ Barcelona Barcelona Spain E-08036 E-08036 Barcelona, Spain
Citazione:
M.C. Cid e C. Vilardell, "Tissue targeting and disease patterns in systemic vasculitis", BEST PR R C, 15(2), 2001, pp. 259-279

Abstract

The systemic vasculitides include a group of diseases with highly heterogeneous organ distribution and disease expression patterns. The mechanisms mediating tissue targeting in systemic vasculitis are largely unknown. Mechanical forces may contribute to the distribution of lesions in immune complex-mediated vasculitis. The site at which the antigen is encountered may be crucial in determining the location of inflammatory infiltrates in some vasculitides. Coexistence of different immunopathogenic mechanisms with variable dominance may generate diversity in disease presentation patterns. Heterogeneous and incompletely understood triggering mechanisms attract inflammatory cells to the site of interest through sophisticated molecular mechanisms: interplay between leukocyte receptors and endothelial ligands, and interactions between chemokines and chemokine receptors. Even with a similar distribution of lesions, patients with vasculitis may display highly variable clinical manifestations. Variations in genes involved in immune response might determine the severity of disease, the intensity of the systemic inflammatory response, the degree of vessel occlusion and the response to therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:36:28