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Titolo:
Pathogenesis: immunogenetic factors
Autore:
Huang, DR; Zhou, YH; Hoffman, GS;
Indirizzi:
Cleveland Clin Fdn, Dept Neurosci NC3 106, Lerner Res Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 s Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Rheumat & Immunol Dis, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ol Dis, Cleveland, OH 44195 USA Cleveland Clin Fdn, Ctr Vasculitis Care & Res, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 & Res, Cleveland, OH 44195 USA
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 239 - 258
SICI:
1521-6942(200106)15:2<239:PIF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GIANT-CELL ARTERITIS; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; SYSTEMIC NECROTIZING VASCULITIS; FACTOR-ALPHA PROMOTER; FAMILIAL POLYARTERITIS-NODOSA; DEPENDENT DIABETES-MELLITUS; PARVOVIRUS B19 INFECTION; LARGE-VESSEL ARTERITIS; GAMMA RECEPTOR-IIIB;
Keywords:
systemic vasculitis; polymorphisms; genetics; cytokine; cytotoxic T lymphocyte; associated antigen 4; MHC; Takayasu's arteritis; giant cell arteritis; Wegener's granulomatosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, DR Cleveland Clin Fdn, Dept Neurosci NC3 106, Lerner Res Inst, 9500Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 95 USA
Citazione:
D.R. Huang et al., "Pathogenesis: immunogenetic factors", BEST PR R C, 15(2), 2001, pp. 239-258

Abstract

The occurrence, albeit infrequent, of systemic vasculitis in closely related family members suggests that both environmental and genetic factors may play a role in the pathogenesis of these diseases. Malfunction of immune regulation in the systemic vasculitides may indicate a role for genes that encode molecules critical to the immune responses. The extremely polymorphic sequences of MHC molecules may provide a structural basis for associations of MHC genes and systemic vasculitis. This review summarizes recent reportsof MHC associations, mechanisms by which MHC may play a role in certain vasculitides, and also examines the role for genes encoding non-MHC molecules, such as Fc gamma receptors, cytokines and T cell co-stimulators. Data suggest that the pathogenesis of systemic vasculitides such as giant-cell arteritis, Taltayasu's arteritis and Wegener's granulomatosis might be governedby multiple genes encoding host defence molecules, in conjunction with environmental factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:55:05