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Titolo:
Postmenopausal estrogen use, type of menopause, and lens opacities - The Framingham studies
Autore:
Worzala, K; Hiller, R; Sperduto, RD; Mutalik, K; Murabito, JM; Moskowitz, M; DAgostino, RB; Wilson, PWF;
Indirizzi:
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA Boston Univ Boston MAUSA 02215 v, Dept Math & Stat, Boston, MA 02215 USA Boston Univ, Endocrinol Sect, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 iv, Endocrinol Sect, Boston, MA 02215 USA Boston Univ, Gen Internal Med Sect, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 n Internal Med Sect, Boston, MA 02215 USA NHLBI, Framingham, MA USA NHLBI Framingham MA USANHLBI, Framingham, MA USA NEI, Div Epidemiol & Clin Res, Bethesda, MD 20892 USA NEI Bethesda MD USA20892 iv Epidemiol & Clin Res, Bethesda, MD 20892 USA Univ Minnesota, Sch Med, Gen Internal Med Sect, Vet Affairs Med Ctr, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ed Ctr, Minneapolis, MN 55455 USA
Titolo Testata:
ARCHIVES OF INTERNAL MEDICINE
fascicolo: 11, volume: 161, anno: 2001,
pagine: 1448 - 1454
SICI:
0003-9926(20010611)161:11<1448:PEUTOM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAVER DAM EYE; HORMONE REPLACEMENT THERAPY; AGE-RELATED CATARACTS; BLUE MOUNTAINS EYE; BODY-MASS INDEX; CIGARETTE-SMOKING; RISK-FACTORS; SUBCAPSULAR CATARACTS; PREVALENCE; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hiller, R NEI, Div Epidemiol & Clin Res, Bldg 31,Room 6A52-31 Ctr Dr MSC 2510, Bethesda, MD 20892 USA NEI Bldg 31,Room 6A52-31 Ctr Dr MSC 2510 Bethesda MD USA 20892 A
Citazione:
K. Worzala et al., "Postmenopausal estrogen use, type of menopause, and lens opacities - The Framingham studies", ARCH IN MED, 161(11), 2001, pp. 1448-1454

Abstract

Background: Previous studies of estrogen replacement therapy and lens opacities have not reported consistent findings. Objective: To investigate whether postmenopausal estrogen use is associated with the occurrence of age-related lens opacities (nuclear, cortical, andposterior subcapsular). Methods: Surviving members of the original cohort of the Framingham Heart Study who also participated in the Framingham Eye Study (1986-1989) were examined for the absence or presence of lens opacities. Data from the Framingham Heart Study, including information on menopausal status (collected biennially from approximately 1948) and use of estrogen replacement therapy (collected biennially from approximately 1960) were used to examine associations between lens opacities and duration of postmenopausal estrogen use, typeof menopause, and age at menopause. Five hundred twenty-nine women, aged 66 to 93 years, were included. Multivariable-adjusted odds ratios of specific types of lens opacities were calculated for (1) duration of estrogen use (never and 1-2, 3-9, and greater than or equal to 10 years), (2) surgical vs natural menopause, and (3) age at menopause. Results: Longer duration of postmenopausal estrogen therapy was inversely associated with the presence of nuclear lens opacities in an adjusted model. Women who had taken estrogen for 10 years or longer had a 60% reduction in risk compared with nonusers (odds ratio, 0.4; 95% confidence interval, 0.2-1.01). Longer duration of estrogen use was associated with fewer posterior subcapsular opacities at a borderline level of significance. No association was noted fur cortical opacities. The risk of posterior subcapsular opacities was significantly increased for women who had undergone surgical menopause compared with women with natural menopause (odds ratio, 2.2; 95% confidence interval, 1.1-4.3). No association was noted for lens opacities and age at menopause. Conclusion: Data from our study and other studies suggest that a reductionin the risk of lens opacities may be an additional benefit of postmenopausal estrogen use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:39:03