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Titolo:
Reductions in occipital cortex GABA levels in panic disorder detected withH-1-magnetic resonance spectroscopy
Autore:
Goddard, AW; Mason, GF; Almai, A; Rothman, DL; Behar, KL; Petroff, OAC; Charney, DS; Krystal, JH;
Indirizzi:
Yale Univ, Dept Psychiat, Yale Anxiety Clin, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 le Anxiety Clin, New Haven, CT 06511 USA Yale Univ, Dept Biomed Engn, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 ept Biomed Engn, New Haven, CT 06511 USA Yale Univ, Dept Internal Med, New Haven, CT 06511 USA Yale Univ New HavenCT USA 06511 pt Internal Med, New Haven, CT 06511 USA Yale Univ, Dept Radiol, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 iv, Dept Radiol, New Haven, CT 06511 USA Yale Univ, Dept Neurol, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 iv, Dept Neurol, New Haven, CT 06511 USA NIMH, Rockville, MD 20857 USA NIMH Rockville MD USA 20857NIMH, Rockville, MD 20857 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 6, volume: 58, anno: 2001,
pagine: 556 - 561
SICI:
0003-990X(200106)58:6<556:RIOCGL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; BENZODIAZEPINE RECEPTOR-BINDING; BRAIN GABA; IOMAZENIL-SPECT; CORTICAL GABA; HOMOCARNOSINE; VIGABATRIN; EPILEPSY; ANXIETY; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Goddard, AW Yale Univ, Dept Psychiat, Yale Anxiety Clin, 100 York St,Room 2J, New Haven, CT 06511 USA Yale Univ 100 York St,Room 2J New Haven CT USA 06511 06511 USA
Citazione:
A.W. Goddard et al., "Reductions in occipital cortex GABA levels in panic disorder detected withH-1-magnetic resonance spectroscopy", ARCH G PSYC, 58(6), 2001, pp. 556-561

Abstract

Background: There is preclinical evidence and indirect clinical evidence implicating gamma -aminobutyric acid (GABA) in the pathophysiology and treatment of human panic disorder. Specifically, deficits in GABA neuronal function have been associated with anxiogenesis, whereas enhancement of GABA function tends to be anxiolytic. Although reported peripheral GABA levels leg,in cerebrospinal fluid and plasma) have been within reference limits in panic disorder, thus far there has been no direct assessment of brain GABA levels in this disorder. The purpose of the present work was to determine whether cortical GABA levels are abnormally low in patients with panic disorder. Methods: Total occipital cortical GABA levels (GABA plus homocarnosine) were assessed in 14 unmedicated patients with panic disorder who did not havemajor depression and 14 retrospectively age- and sex-marched control subjects using spatially localized H-1-magnetic reso-nance spectroscopy. All patients met DSM-IV criteria for a principal current diagnosis of panic disorder with or without agoraphobia. Results: Patients with panic disorder had a 22% reduction in total occipital cortex GABA concentration (GABA plus homocarnosine) compared with controls. This finding was present in 12 of 14 patient-control pairs and was not solely accounted for by medication history. There were no significant correlations between occipital cortex GABA levels and measures of illness or state anxiety. Conclusions: Panic disorder is associated with reductions in total occipital cortex GABA levels. This abnormality might contribute to the pathophysiology, of panic disorder.

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Documento generato il 27/01/20 alle ore 07:20:28