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Titolo:
Resistance profiles to antiretroviral drugs in HIV-1 drug-naive patients in Argentina
Autore:
Kijak, GH; Pampuro, SE; Avila, MM; Zala, C; Cahn, P; Wainberg, MA; Salomon, H;
Indirizzi:
Univ Buenos Aires, Sch Med, Dept Microbiol, Natl Reference Ctr AIDS, RA-1053 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF ArgentinaRA-1053 Aires, DF, Argentina Huesped Fdn, Buenos Aires, DF, Argentina Huesped Fdn Buenos Aires DF Argentina d Fdn, Buenos Aires, DF, Argentina McGill Univ, AIDS Ctr, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Gill Univ, AIDS Ctr, Montreal, PQ, Canada
Titolo Testata:
ANTIVIRAL THERAPY
fascicolo: 1, volume: 6, anno: 2001,
pagine: 71 - 77
SICI:
1359-6535(200103)6:1<71:RPTADI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE; PROTEASE INHIBITOR; POINT MUTATIONS; INFECTION; ZIDOVUDINE; THERAPY; SENSITIVITY; PREVALENCE; MUTANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Salomon, H Univ Buenos Aires, Sch Med, Dept Microbiol, Natl Reference Ctr AIDS, RA-1053 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1053 Argentina
Citazione:
G.H. Kijak et al., "Resistance profiles to antiretroviral drugs in HIV-1 drug-naive patients in Argentina", ANTIVIR TH, 6(1), 2001, pp. 71-77

Abstract

The drug resistance profile of treatment-naive HIV-infected individuals living in Buenos Aires, Argentina, was studied. Samples taken from 94 drug-naive individuals with established HIV infection and 13 patients with primaryHIV infection were assessed by nucleotide sequencing and LiPA. The prevalence of drug-associated primary mutations in individuals with established infection was very low. In the viral protease region, 1/86 (1.2%) individualscarried the D30N mutation, whereas 1/85 (1.2%) had the M41L mutation in the reverse transcriptase (RT) region. Secondary mutations in both the protease and RT regions were found in almost 90% of the individuals. In individuals with primary infection, primary mutations were detected in 2/13 (15.4%) patients, one of them carrying M461 mutation in the protease while the other patient had a mutation at codon 184 of the RT. In accordance with currentdrug resistance testing guidelines, the results of this study suggest thatsusceptibility tests need not be performed at this time prior to initiation of antiretroviral therapy in HIV-l-infected people in Argentina. However,the public health implications of this subject warrant follow-up studies that will examine a larger number of drug-naive patients, not only in BuenosAires but also in other major Argentinian cities and in rural areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:23:10