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Titolo:
A functional magnetic resonance imaging study of auditory mismatch in schizophrenia
Autore:
Wible, CG; Kubicki, M; Yoo, SS; Kacher, DF; Salisbury, DF; Anderson, MC; Shenton, ME; Hirayasu, Y; Kikinis, R; Jolesz, FA; McCarley, RW;
Indirizzi:
Brockton Vet Affairs Med Ctr, Dept Psychiat, Brockton, MA 02401 USA Brockton Vet Affairs Med Ctr Brockton MA USA 02401 Brockton, MA 02401 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA Brigham & Womens Hosp, Surg Planning Lab, Dept Radiol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Radiol, Boston, MA 02115 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 6, volume: 158, anno: 2001,
pagine: 938 - 943
SICI:
0002-953X(200106)158:6<938:AFMRIS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVITY MMN GENERATION; HUMAN EXTRASTRIATE CORTEX; LEFT TEMPORAL-LOBE; STIMULUS DEVIANCE; WORKING-MEMORY; PLANUM TEMPORALE; VOLUME REDUCTION; HESCHL GYRUS; HALLUCINATIONS; ATTENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: McCarley, RW Brockton Vet Affairs Med Ctr, Dept Psychiat, 116A,940 BelmontSt, Brockton, MA 02401 USA Brockton Vet Affairs Med Ctr 116A,940 Belmont St Brockton MA USA 02401
Citazione:
C.G. Wible et al., "A functional magnetic resonance imaging study of auditory mismatch in schizophrenia", AM J PSYCHI, 158(6), 2001, pp. 938-943

Abstract

Objective: Previous research has noted functional and structural temporal lobe abnormalities in schizophrenia that relate to symptoms such as auditory hallucinations and thought disorder. The goal of the study was to determine whether the functional abnormalities are present in schizophrenia at early stages of auditory processing. Method: Functional magnetic resonance imaging activity was examined duringthe presentation of the mismatch stimuli, which are deviant tones embeddedin a series of standard tones. The mismatch stimuli are used to elicit themismatch negativity, an early auditory event-related potential. Ten patients with schizophrenia and 10 comparison subjects were presented the mismatch stimuli condition and a control condition in which only one tone was presented repeatedly. Results: The superior temporal gyrus showed the most prevalent and consistent activation. The superior temporal gy rus showed less activation in the schizophrenic subjects than in the comparison subjects only during the mismatch stimuli condition. Conclusions: This result is consistent with those of mismatch negativity event-related potential studies and suggests that early auditory processing is abnormal in chronic schizophrenia.

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Documento generato il 25/01/20 alle ore 19:09:12