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Titolo:
Impact of clozapine on completed suicide
Autore:
Sernyak, MJ; Desai, R; Stolar, M; Rosenheck, R;
Indirizzi:
VA Connecticut Healthcare Syst, Psychiat Serv 116A, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA VA NE Program Evaluat Ctr, W Haven, CT USA VA NE Program Evaluat Ctr W Haven CT USA am Evaluat Ctr, W Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Publ Hlth, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Publ Hlth, New Haven, CT 06520 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 6, volume: 158, anno: 2001,
pagine: 931 - 937
SICI:
0002-953X(200106)158:6<931:IOCOCS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-RESISTANT SCHIZOPHRENIA; RISK-FACTORS; PROPENSITY SCORE; OUTPATIENTS; DEPRESSION; MORTALITY; PATTERNS; STATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sernyak, MJ VA Connecticut Healthcare Syst, Psychiat Serv 116A, W Haven Campus,950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare SystW Haven Campus,950 Campbell Ave W Haven CT USA 06516
Citazione:
M.J. Sernyak et al., "Impact of clozapine on completed suicide", AM J PSYCHI, 158(6), 2001, pp. 931-937

Abstract

Objective: Clozapine has been found to be superior to typical neurolepticsin ameliorating the symptoms of refractory schizophrenia. This study evaluated clozapine's effect on the rate of death due to suicide. Method: All patients over a 4-year period who initiated treatment with clozapine while hospitalized within the Department of Veterans Affairs (VA) system (N=1,415) were matched with a schizophrenic control group (N=2,830) bypropensity scoring-a widely accepted statistical method that has been usedrelatively little in psychiatric research. Centralized VA databases and a national death registry were used to identify all deaths within the two groups, along with listed causes, for the 3 years after discharge. Results: Veterans exposed to clozapine while inpatients were significantlyless likely to die during the follow-up period than those in the control group, but this was entirely attributable to the much lower rate of death due to respiratory disorders in the clozapine group. There were no significant differences in rates of suicide or accidental death. Conclusions: These results fail to support the hypothesis that clozapine treatment is associated with significantly fewer deaths due to suicide.

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Documento generato il 05/12/20 alle ore 01:24:57