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Titolo:
No support for regional selectivity in clozapine-treated patients: A PET study with [C-11]raclopride and [C-11]FLB 457
Autore:
Talvik, M; Nordstrom, AL; Nyberg, S; Olsson, H; Halldin, C; Farde, L;
Indirizzi:
Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 osci, S-17176 Stockholm, Sweden
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 6, volume: 158, anno: 2001,
pagine: 926 - 930
SICI:
0002-953X(200106)158:6<926:NSFRSI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; SCHIZOPHRENIC-PATIENTS; DOPAMINE-RECEPTORS; ANTIPSYCHOTIC-DRUGS; NEUROLEPTIC DRUGS; CLINICAL-RESPONSE; HUMAN-BRAIN; BINDING; D-2; HALOPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Talvik, M Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 176 Stockholm, Sweden
Citazione:
M. Talvik et al., "No support for regional selectivity in clozapine-treated patients: A PET study with [C-11]raclopride and [C-11]FLB 457", AM J PSYCHI, 158(6), 2001, pp. 926-930

Abstract

Objective: The authors' goal was to test the hypothesis of extrastriatal D-2 receptor selectivity as the mechanism of action of clozapine. Method: Positron emission tomography (PET) was used to examine extrastriatal as well as striatal dopamine D-2 receptor occupancy in four patients treated with clozapine and three patients treated with haloperidol. The reference radioligand [C-11]raclopride was used for determination of D-2 receptoroccupancy in the striatum. The radioligand [C-11]FLB 457 was chosen for determination of D-2 receptor occupancy in the thalamus, the temporal cortex.and the frontal. Results: In patients treated with haloperidol the D-2 receptor occupancy was high in all examined brain regions. In clozapine-treated patients the D-2 receptor occupancy was relatively low in both the striatum and the extrastriatal regions. Conclusions: The results from the present study give no support for the hypothesis of regional selectivity as the mechanism of action for clozapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:26:22