Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Growth hormone receptor gene variant and mandibular height in the normal Japanese population
Autore:
Yamaguchi, T; Maki, K; Shibasaki, Y;
Indirizzi:
Showa Univ, Sch Dent, Dept Orthodont, Outa Ku, Tokyo 1458515, Japan Showa Univ Tokyo Japan 1458515 Orthodont, Outa Ku, Tokyo 1458515, Japan
Titolo Testata:
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
fascicolo: 6, volume: 119, anno: 2001,
pagine: 650 - 653
SICI:
0889-5406(200106)119:6<650:GHRGVA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC SHORT STATURE; BINDING-PROTEIN; MUTATIONS; CHILDREN; INSENSITIVITY; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, T Showa Univ, Sch Dent, Dept Orthodont, Outa Ku, 2-1-1 Kitasenzoku, Tokyo 1458515, Japan Showa Univ 2-1-1 Kitasenzoku Tokyo Japan 14585158515, Japan
Citazione:
T. Yamaguchi et al., "Growth hormone receptor gene variant and mandibular height in the normal Japanese population", AM J ORTHOD, 119(6), 2001, pp. 650-653

Abstract

This study was aimed at quantitatively evaluating the relationship betweencraniofacial morphology and the Pro561Thr (P561T) variant in the growth hormone receptor gene (GHR), which is considered to be an important factor incraniofacial and skeletal growth. The subjects were unrelated individuals in a normal Japanese population and consisted of 50 men and 50 women. With the use of genomic DNA extracted from whole blood, the GHR gene P561T variant was detected by the polymerase chain reaction-restriction fragment length polymorphism method (with the restriction enzyme Stul). The relationshipsof the genotypes to body height and 5 linear measurements from lateral cephalograms were examined for evaluation of craniofacial morphology. The normal Japanese population without P561T had a significantly greater mandibularramus length (condylion-gonion) than did those with P561T. This suggests that the GHR gene P561T variant may be associated with mandibular height growth and can be a genetic marker for it. Further studies about such genetic markers may expand our understanding of the genetic control in craniofacialmorphological determinants and help in the prediction of craniofacial growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:55:16