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Titolo:
Correction of carotid augmentation index for heart rate in elderly essential hypertensives
Autore:
Gatzka, CD; Cameron, JD; Dart, AM; Berry, KL; Kingwell, BA; Dewar, EM; Reid, CM; Jennings, GLR;
Indirizzi:
Baker Med Res Inst, Alfred & Baker Med Unit, Prahran, Vic 3181, Australia Baker Med Res Inst Prahran Vic Australia 3181 rahran, Vic 3181, Australia La Trobe Univ, Melbourne, Vic, Australia La Trobe Univ Melbourne Vic Australia be Univ, Melbourne, Vic, Australia
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 6, volume: 14, anno: 2001,
parte:, 1
pagine: 573 - 577
SICI:
0895-7061(200106)14:6<573:COCAIF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE PRESSURE; CARDIOVASCULAR MORTALITY; ARTERIAL COMPLIANCE; AORTIC PRESSURE; POPULATION; VELOCITY; SYSTEM; SAMPLE;
Keywords:
arterial stiffness; pulse wave velocity; heart rate; arterial wave reflection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gatzka, CD Alfred Hosp, Alfred & Baker Med Unit, Commercial Rd, Prahran, Vic 3181, Australia Alfred Hosp Commercial Rd Prahran Vic Australia 3181 Australia
Citazione:
C.D. Gatzka et al., "Correction of carotid augmentation index for heart rate in elderly essential hypertensives", AM J HYPERT, 14(6), 2001, pp. 573-577

Abstract

Carotid augmentation index (AI) is used as a surrogate measure of arterialstiffness. Although arterial stiffness has been shown to either remain unchanged or increase with an increase in heart rate, AI decreases as heart rate increases. This study aimed to quantify this confounding effect of heartrate on Al. We investigated 873 hypertensives, mean age 72 +/- 5 years, 44% men, mean brachial blood pressure 161 +/- 21/82 +/- 11 mm Hg. Carotid artery tonometry with simultaneous continuous wave Doppler measurement of ascending aorticblood flow was performed. Al was calculated from the carotid pressure waveform. Waveforms were decomposed into their forward and backward components and the time to reflection between the maxima of the forward and backward pressure waves was measured. Al showed a stronger (P < .001) association with ejection time (r = 0.48, P < .001) than with heart rate (r = -0.28, P < .001). Although Al is strongly related to the time to reflection (r = -0.51, P < .001), only a weak association was seen between time to reflection and heart rate (r = 0.16, P < .001) or ejection time (r = -0.12, P < .001), Our analysis in an elderly cohort of patients with essential hypertension demonstrates that Al is related to the time to reflection. It also reiterates that Al is confounded by heart rate without any underlying heart rate-dependent change in wave reflection. In population-based studies the confounding effect of heart rate can potentially be corrected. AI remains strongly (r = -0.52) related to time toreflection after correction for the effects of ejection time on AI. (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:13:48