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Titolo:
Low-dose alpha/beta blockade in the treatment of essential hypertension
Autore:
Mann, SJ; Gerber, LM;
Indirizzi:
Cornell Univ, Weill Med Coll, Presbyterian Hosp, New York, NY 10021 USA Cornell Univ New York NY USA 10021 sbyterian Hosp, New York, NY 10021 USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 6, volume: 14, anno: 2001,
parte:, 1
pagine: 553 - 558
SICI:
0895-7061(200106)14:6<553:LABITT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMBULATORY BLOOD-PRESSURE; TO-MODERATE HYPERTENSION; ANTIHYPERTENSIVE AGENTS; DOUBLE-BLIND; EFFICACY; PLACEBO; MILD; COMBINATION; DOXAZOSIN; ATENOLOL;
Keywords:
drug therapy for hypertension; alpha-adrenergic blocker; beta-adrenergic blocker; diuretic; angiotensin converting enzyme inhibitor; home blood pressure monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, SJ Cornell Univ, Weill Med Coll, Presbyterian Hosp, Starr 4,525 E 68th St, New York, NY 10021 USA Cornell Univ Starr 4,525 E 68th St New York NY USA 10021 0021 USA
Citazione:
S.J. Mann e L.M. Gerber, "Low-dose alpha/beta blockade in the treatment of essential hypertension", AM J HYPERT, 14(6), 2001, pp. 553-558

Abstract

Despite the recent emphasis on combination drug therapy for hypertension, little attention has been given to alpha/beta blockade using agents other than labetalol. The purpose of this study was to 1) compare the efficacy of low-dose alpha/beta blockade using doxazosin + betaxolol, versus monotherapy with an angiotensin converting enzyme inhibitor (quinapril) and a diuretic (hydrochlorothiazide [HCTZ]), and 2) assess the efficacy of low-dose doxazosin. In a crossover study, 21 hypertensive subjects were treated for 3 weeks each with HCTZ, 12.5 to 25 mg/day, quinapril, 10 to 40 mg/day, and 3 combination of doxazosin, 1 to 4 mg + betaxolol, 5 to 10 mg daily. Doses weretitrated to achieve a systolic pressure < 130 mm Hg, as assessed by self-recorded home measurements. Home blood pressure decreased 11.5/7.5 mm Hg after HCTZ, 12.9/8.8 mm Hg after quinapril, and 21.2/16.5 mm Hg after doxazosin + betaxolol (P < .001/< .001 v HCTZ and P < .002/< .001 v quinapril). Thetarget systolic pressure was achieved by 33%, 43%, and 71% of subjects, respectively (P = .04 v HCTZ, and .03 v quinapril). Among the 8 subjects in whom doxazosin dosage was increased to the maximum of 4 mg, the mean blood pressure achieved at 4 mg did not differ from that achieved at 2 mg (136/87 v 136/88 mm Hg). We conclude that oral alpha/beta blockade is superior to monotherapy with an angiotensin converting enzyme inhibitor or a diuretic and that maximal or near maximal efficacy can be achieved at a 2-mg dose of doxazosin. Low-dose oral alpha/beta blockade merits greater consideration inthe drug therapy of essential hypertension. (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:42:33