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Titolo:
Evaluation of the placebo effect and reproducibility of blood pressure measurement in hypertension
Autore:
Asmar, R; Safar, M; Queneau, P;
Indirizzi:
Inst CardioVasc, F-75016 Paris, France Inst CardioVasc Paris France F-75016 t CardioVasc, F-75016 Paris, France Hop Broussais, Serv Med 1, F-75674 Paris, France Hop Broussais Paris France F-75674 is, Serv Med 1, F-75674 Paris, France Hop Bellevue, Serv Med Interne, St Etienne, France Hop Bellevue St Etienne France ue, Serv Med Interne, St Etienne, France
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 6, volume: 14, anno: 2001,
parte:, 1
pagine: 546 - 552
SICI:
0895-7061(200106)14:6<546:EOTPEA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE PRESSURE; CARDIOVASCULAR MORTALITY; MYOCARDIAL-INFARCTION; PREDICTOR; RISK;
Keywords:
blood pressure; placebo; ambulatory blood pressure monitoring; regression to the mean; reproducibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Asmar, R Inst CardioVasc, F-75016 Paris, France Inst CardioVasc Paris France F-75016 asc, F-75016 Paris, France
Citazione:
R. Asmar et al., "Evaluation of the placebo effect and reproducibility of blood pressure measurement in hypertension", AM J HYPERT, 14(6), 2001, pp. 546-552

Abstract

Pharmacologic studies in hypertension often describe blood pressure (BP) reductions in placebo control groups. This placebo effect is currently debated, as it seems to be related to BP measurement methods and as a regressionto the mean phenomenon may lead to misinterpretation. Furthermore, data onpulse pressure are lacking. This study was designed to evaluate the placebo effect on BP and to differentiate it from regression to the mean. According to a crossover design, 26 mild-to-moderate hypertensive patients who were treated with placebo or given no treatment were followed-up for 1 month. Clinic and ambulatory BP was assessed at baseline and at the end of each 1-month period. Placebo administration resulted in significant reductions in clinic systolic, diastolic, and mean BP (P < .01), ambulatory 24-h SEP (P <.05), and daytime systolic, diastolic, and mean BP (P < .01, P < .05, P < .01, respectively). No significant differences were noted for pulse pressure and heart rate or between BP values measured at baseline and after 1 month without treatment, Despite a significant correlation between changes in clinic and ambulatory BP, the scatter of individual data suggests that the placebo response observed with one method cannot be systematically extrapolated to the other method. This study conclusively shows the effect of placebo in mild-to-moderate hypertension on both clinic and ambulatory systolic, diastolic, and mean BP, in which it has been shown to differ from the regression to the mean phenomenon. This effect was not observed for pulse pressure or heart rate. (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:20:24