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Titolo:
Physiology of hot flashes
Autore:
Freedman, RR;
Indirizzi:
Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI USA Wayne State Univ Detroit MI USA ychiat & Behav Neurosci, Detroit, MI USA Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI USA Wayne State UnivDetroit MI USA , Dept Obstet & Gynecol, Detroit, MI USA
Titolo Testata:
AMERICAN JOURNAL OF HUMAN BIOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 453 - 464
SICI:
1042-0533(200107/08)13:4<453:POHF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORE BODY-TEMPERATURE; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; MENOPAUSAL FLUSHES; SKIN TEMPERATURE; MODULATION; SECRETION; YOHIMBINE; RESPONSES; NALOXONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Freedman, RR Wayne State Univ, CS Mott Ctr, 275 E Hancock Ave, Detroit, MI48201 USA Wayne State Univ 275 E Hancock Ave Detroit MI USA 48201 1 USA
Citazione:
R.R. Freedman, "Physiology of hot flashes", AM J HUM B, 13(4), 2001, pp. 453-464

Abstract

Hot flashes are the most common symptom of the climacteric, although prevalence estimates are lower in some rural and non-Western areas. The symptomsare characteristic of a heat-dissipation response and consist of sweating on the face, neck, and chest, as well as peripheral vasodilation. Although hot flashes clearly accompany the estrogen withdrawal at menopause, estrogen alone is not responsible since levels do not differ between symptomatic and asymptomatic women. ne Until recently it was thought that hot flashes were triggered by a sudden, downward resetting of the hypothalamic setpoint, since there was no evidence of increased core body temperature. Evidence obtained using a rapidly responding ingested telemetry pill indicates that the thermoneutral zone, within which sweating, peripheral vasodilation, and shivering do not occur, is virtually nonexistent in symptomatic women but normal (about 0.4 degreesC) in asymptomatic women. The results suggest that small temperature elevations preceding hot flashes acting within a reduced thermoneutral zone constitute the triggering mechanism. Central sympathetic activation is also elevated in symptomatic women which, in animal studies, reduces the thermoneutral zone. Clonidine reduces central sympathetic activation, widens the thermoneutral zone, and ameliorates hot flashes. Estrogenvirtually eliminates hot flashes but its mechanism of action is not known. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:40:27