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Titolo:
Mitochondria-based photodynamic anti-cancer therapy
Autore:
Morgan, J; Oseroff, AR;
Indirizzi:
Roswell Pk Canc Inst, Dept Dermatol, Buffalo, NY 14263 USA Roswell Pk CancInst Buffalo NY USA 14263 Dermatol, Buffalo, NY 14263 USA
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 71 - 86
SICI:
0169-409X(20010702)49:1-2<71:MPAT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-AMINOLEVULINIC-ACID; PHOTOFRIN-II PHOTOSENSITIZATION; MOUSE LYMPHOMA-CELLS; BENZODIAZEPINE RECEPTOR LIGANDS; ELECTRON-TRANSPORT CHAIN; MYELOID-LEUKEMIA CELLS; CYTOCHROME-C RELEASE; SUBCELLULAR-LOCALIZATION; 5-AMINOLEVULINIC ACID; CARCINOMA-CELLS;
Keywords:
photosensitizer; phototoxicity; subcellular localization; target; binding site; mitochondrial damage; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Morgan, J Roswell Pk Canc Inst, Dept Dermatol, MRC2,Elm & Carlton St, Buffalo, NY 14263 USA Roswell Pk Canc Inst MRC2,Elm & Carlton St Buffalo NY USA14263
Citazione:
J. Morgan e A.R. Oseroff, "Mitochondria-based photodynamic anti-cancer therapy", ADV DRUG DE, 49(1-2), 2001, pp. 71-86

Abstract

As photodynamic therapy (PDT) becomes established as a treatment for cancer, there is increasing interest in identifying critical mechanisms of cell killing and understanding the bases for effective photosensitizers. The existence of multiple cellular targets makes it difficult to distinguish the critical events leading to cell death from PDT. However, with more sensitivetechniques to detect photosensitizer localization, the isolation of PDT-resistant and -sensitive mutants and the use of innovative molecular and biochemical strategies to map cellular events occurring during and after photosensitization, some order is emerging from the chaos. The subcellular localization of many photosensitizers and the early responses to light activationindicate that mitochondria play a major role in photodynamic cell death. PDT with many agents which damage or inhibit different or multiple mitochondrial targets has many of the desirable characteristics for an effective anti-cancer therapy. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:08:23