Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
Autore:
Modica-Napolitano, JS; Aprille, JR;
Indirizzi:
Merrimack Coll, Dept Biol, N Andover, MA 01845 USA Merrimack Coll N Andover MA USA 01845 Dept Biol, N Andover, MA 01845 USA Tufts Univ, Dept Biol, Medford, MA 02155 USA Tufts Univ Medford MA USA 02155 ts Univ, Dept Biol, Medford, MA 02155 USA
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 1-2, volume: 49, anno: 2001,
pagine: 63 - 70
SICI:
0169-409X(20010702)49:1-2<63:DLCSTT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL BENZODIAZEPINE RECEPTOR; ADENINE-NUCLEOTIDE TRANSLOCASE; BOVINE HEART MITOCHONDRIAL; RAT-LIVER MITOCHONDRIA; HUMAN GLIOMA-CELLS; LIVING CELLS; OXIDATIVE-PHOSPHORYLATION; HEPATOCELLULAR-CARCINOMA; DIFFERENTIAL RETENTION; ANTICARCINOMA ACTIVITY;
Keywords:
delocalized lipophilic cations; cell killing; tumor; chemotheraputic agents; mitochondria;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Modica-Napolitano, JS Merrimack Coll, Dept Biol, 315 Turnpike St, N Andover, MA 01845 USA Merrimack Coll 315 Turnpike St N Andover MA USA 01845
Citazione:
J.S. Modica-Napolitano e J.R. Aprille, "Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells", ADV DRUG DE, 49(1-2), 2001, pp. 63-70

Abstract

Traditional chemotherapies, aimed at DNA replication in rapidly dividing cells, have achieved only limited success in the treatment of carcinomas duelargely to their lack of specificity for cells of tumorigenic origin. It is important, therefore, to investigate treatment strategies aimed at novel cellular targets that are sufficiently different between normal cells and cancer cells so as to provide a basis for selective tumor cell killing. Delocalized lipophilic cations (DLCs) are concentrated by cells and into mitochondria in response to negative inside transmembrane potentials. The higher plasma and/or mitochondrial membrane potentials of carcinoma cells comparedto normal epithelial cells account for the selective accumulation of DLCs in carcinoma mitochondria. Since most DLCs are toxic to mitochondria at high concentrations, their selective accumulation in carcinoma mitochondria and consequent mitochondrial toxicity provide a basis for selective carcinomacell killing. Several of these compounds have already displayed some degree of efficacy as chemotherapeutic agents in vitro and in vivo. The effectiveness of DLCs can also be enhanced by their use in photochemotherapy or combination drug therapy. Discovery of the biochemical differences that account for the higher membrane potentials in carcinoma cells is expected to leadto the design of new DLCs targeted specifically to those differences, resulting in even greater selectivity and efficacy for tumor cell killing. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:39:23