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Titolo:
Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways
Autore:
Fang, LB; Wu, Y; Zhang, LF; Fan, WQ;
Indirizzi:
Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310006, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310006 ou 310006, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 6, volume: 22, anno: 2001,
pagine: 561 - 565
SICI:
0253-9756(200106)22:6<561:IBNOEN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ENDINGS; CHANNEL CURRENT; SENSORY NERVES; ORPHANIN-FQ; RECEPTOR; NEUROPEPTIDE; STIMULATION; INNERVATION; MODULATION; TRACHEA;
Keywords:
nociceptin; kappa opioid receptors; bronchi; smooth muscle; guinea pigs; electric stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Fang, LB Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310006, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310006 , Peoples R China
Citazione:
L.B. Fang et al., "Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways", ACT PHAR SI, 22(6), 2001, pp. 561-565

Abstract

AIM: To study the effect of nociceptin (NC), a newly discovered heptadecapeptide, and U-50488H, a kappa-opioid receptor agonist, on excitatory non-adrenergic noncholinergic (eNANC) constriction responses in guinea pig isolated bronchus. METHODS: An eNANC response was induced by electric field stimulation (EFS) in the preparation via activation of the sensory nerve terminals. The effect of NC and U-50488H was analyzed on the response. RESULTS: Nociceptin 0.001 - 0.1 mu mol L-l inhibited the eNANC constriction which was induced by EFS but not by capsaicin in guinea pig bronchus. The constriction inhibited by NC 0.01 mu mol .L-1 was (43 +/- 31) % compared with the control. After pretreatment with naloxone 0.1 mu mol L-l, the constriction was inhibited by (46 +/- 28) %, without marked change compared with the above figure. IC50 (95 % Of confidence Limits) was 6.12 (3.8 - 9.9) nmol .L-1. U-50488H also inhibited the EFS-evoked eNANC constriction and the effect was abolished after pretreatment with naloxone. IC50(95 % of confidence limits) was 1.08 (0.5 -2.2) mu mol .L-1. Capsaicin 0.01-1 mu mol .L-1 caused a cumulative constriction response in the preparation. Moreover, the effect of capsaicin was not affected by pretreatment with NC 0.01 mu mol .L-1 or U-50488H 0.1 mu mol .L-1. The constriction induced by exogenous neurokinin A, were also unaffected by treatment with NC 0.01 mu mol .L-1 or U-50488H 0.1 mu mol .L-1 in isolated bronchus. CONCLUSION: Nociceptin inhibits EFS-induced eNANC constriction, which is not reversed by naloxone, while U-50488H inhibits EFS-induced eNANC response via acitivation of opioid receptor in guineapig airways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:19:24