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Titolo:
Gynecomastia in type-1 neurofibromatosis with features of pseudoangiomatous stromal hyperplasia with giant cells. Report of two cases
Autore:
Damiani, S; Eusebi, V;
Indirizzi:
Univ Bologna, Osped Bellaria, Dept Oncol, Sect Anat Pathol & Cytopathol Marcello Malpighi, I-40139 Bologna, Italy Univ Bologna Bologna Italy I-40139 ello Malpighi, I-40139 Bologna, Italy
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 438, anno: 2001,
pagine: 513 - 516
SICI:
0945-6317(200105)438:5<513:GITNWF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY STROMA; LESIONS; BREAST;
Keywords:
breast; pseudoangiomatous stromal hyperplasia; giant cells; neurofibromatosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Eusebi, V Univ Bologna, Osped Bellaria, Dept Oncol, Sect Anat Pathol & Cytopathol Marcello Malpighi, Via Altura 3, I-40139 Bologna, Italy Univ Bologna Via Altura 3 Bologna Italy I-40139 Bologna, Italy
Citazione:
S. Damiani e V. Eusebi, "Gynecomastia in type-1 neurofibromatosis with features of pseudoangiomatous stromal hyperplasia with giant cells. Report of two cases", VIRCHOWS AR, 438(5), 2001, pp. 513-516

Abstract

We describe the histological finding in two cases of gynecomastia in patients with von Recklinghausen's disease. The histological and immunohistochemical features of the two cases were reviewed and compared with those of five cases of gynecomastia in men without clinical evidence of neurofibromatosis. In both patients bearing von Recklinghausen's disease, the breast stroma showed features consistent with pseudoangiomatous stromal hyperplasia (PASH). It was characterised by anastomosing empty spaces lined by spindle andmultinucleated giant cells which were positive with CD34 and anti-vimentinantisera and negative with anti-FVIII and CD31 antisera, In two of five ofthe control cases without neurofibromatosis, the mammary stroma showed focal areas with features of PASH, but no multinucleated giant cells were present in any case. PASH with giant cells should be recognised as a feature ofgynecomastia in von Recklinghausen's disease. The presence of multinucleated giant cells is very unusual and, although more cases have to be studied,these cells seem to be a feature of PASH occurring in patients with von Recklinghausen's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:57:42