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Titolo:
Pancreatic ductal myofibroblasts - Proliferative patterns in various pathologic situations
Autore:
Izumi, M; Suda, K; Torii, A; Inadama, E;
Indirizzi:
Jikei Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,MinatoKu, Tokyo 1058461, Japan Jikei Univ Tokyo Japan 1058461 & Hepatol,MinatoKu, Tokyo 1058461, Japan Juntendo Univ, Sch Med, Dept Pathol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 iv, Sch Med, Dept Pathol, Tokyo 113, Japan
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 5, volume: 438, anno: 2001,
pagine: 442 - 450
SICI:
0945-6317(200105)438:5<442:PDM-PP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE ACTIN; CONTRACTILE INTERSTITIAL-CELLS; ALVEOLAR MYOFIBROBLASTS; GRANULATION-TISSUE; STELLATE CELLS; IN-VITRO; ALPHA; EXPRESSION; DIFFERENTIATION; IDENTIFICATION;
Keywords:
myofibroblast; smooth muscle actin; focal pancreatitis; localized stenosis of the pancreatic duct; obstructive chronic pancreatitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Izumi, M Jikei Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,MinatoKu, 3-25-8 Nishi Shinbashi, Tokyo 1058461, Japan Jikei Univ 3-25-8Nishi Shinbashi Tokyo Japan 1058461 461, Japan
Citazione:
M. Izumi et al., "Pancreatic ductal myofibroblasts - Proliferative patterns in various pathologic situations", VIRCHOWS AR, 438(5), 2001, pp. 442-450

Abstract

Myofibroblasts in the periacinar area of the pancreas have been demonstrated to mediate fibrogenesis in pancreatic fibrosis. However, only a few reports have described myofibroblasts in the pancreatic duct. To elucidate the presence of myofibroblasts in the pancreatic ductal wall, we performed an immunohistochemical study, using immunostains for both alpha -smooth muscle actin (alpha SMA) and desmin, and an electron microscopic study on surgically resected pancreatic specimens from 10, 23, 23, and 56 cases of focal pancreatitis (EP), chronic pancreatitis (CP), pancreatic carcinoma (PCa), and carcinoma of the papilla of Vater (VPCa), respectively. All cases showed localized stenosis of the main pancreatic duct by means of preoperative pancreatography. As controls, 20 autopsy cases were studied, alpha SMA-positive and desmin-negative cells existed in the ductal walls of controls and were revealed as myofibroblasts by means of electron microscopy. In six FPs, proliferation of myofibroblasts was observed at the stenotic portion. In VPCas, myofibroblasts mainly proliferated in the pancreatic ductal wall. In CPs and PCas, no myofibroblast proliferation was observed at the stenotic portion. The proliferation of myofibroblasts might occur as a wound healing process in FP, while acting against elevation of intraductal pressure in VPCa. In conclusion, proliferation of myofibroblasts plays an important role in ductal changes in various pathological situations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:23:17