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Titolo:
Experimental reproduction of winter dysentery in lactating cows using BCV - comparison with BCV infection in milk-fed calves
Autore:
Traven, M; Naslund, K; Linde, N; Linde, B; Silvan, A; Fossum, C; Hedlund, KO; Larsson, B;
Indirizzi:
Swedish Univ Agr Sci, Dept Ruminant Med & Vet Epidemiol, S-75007 Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden S-75007 iol, S-75007 Uppsala, Sweden Natl Vet Inst, Sect Virol, S-75007 Uppsala, Sweden Natl Vet Inst UppsalaSweden S-75007 Sect Virol, S-75007 Uppsala, Sweden Medicago AB, Uppsala, Sweden Medicago AB Uppsala SwedenMedicago AB, Uppsala, Sweden Swedish Univ Agr Sci, Immunol Sect, Dept Vet Microbiol, S-75123 Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden S-75123 iol, S-75123 Uppsala, Sweden Swedish Inst Infect Dis Control, S-17182 Solna, Sweden Swedish Inst InfectDis Control Solna Sweden S-17182 17182 Solna, Sweden
Titolo Testata:
VETERINARY MICROBIOLOGY
fascicolo: 2, volume: 81, anno: 2001,
pagine: 127 - 151
SICI:
0378-1135(20010726)81:2<127:EROWDI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; NEONATAL CALF DIARRHEA; LINKED IMMUNOSORBENT-ASSAY; CORONAVIRUS-LIKE AGENT; BOVINE CORONAVIRUS; ANTIBODY-RESPONSES; DAIRY CALVES; SEROLOGICAL EVIDENCE; MATERNAL ANTIBODIES; ELECTRON-MICROSCOPY;
Keywords:
cattle-bacteria; winter dysentery; bovine coronavirus; experimental infection; IgM; IgA; interferon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Traven, M Swedish Univ Agr Sci, Dept Ruminant Med & Vet Epidemiol, Box 7019, S-75007Uppsala, Sweden Swedish Univ Agr Sci Box 7019 Uppsala Sweden S-75007 la, Sweden
Citazione:
M. Traven et al., "Experimental reproduction of winter dysentery in lactating cows using BCV - comparison with BCV infection in milk-fed calves", VET MICROB, 81(2), 2001, pp. 127-151

Abstract

Infection models were developed for adult cows and for young calves using the same strain of bovine coronavirus (BCV), which for the first time allows experimental reproduction of winter dysentery (WD) in seronegative lactating cows. The cattle were infected through direct contact with an experimentally inoculated calf. All experimental cattle shed faecal BCV with development of diarrhoea, being profusely watery with small amounts of blood in the most severely affected animals. including both cows and calves. The cows,in contrast to the calves, showed depressed general condition and appetiteleading to a marked decrease in milk yield. Further age-associated differences were a shorter incubation period in the two youngest calves, but with milder fever and milder decrease in white blood cell counts. These findingsshed light on the apparent epidemiological differences between WD and calfBCV diarrhoea suggesting that, (1) the same strains of BCV cause natural outbreaks of calf diarrhoea and WD, (2) seronegative cows are more severely affected by the infection than seronegative conventionally reared calves, and (3) unaffected general condition in diarrhoeic calves may lead to underestimation of the occurrence of calf diarrhoea in WD outbreaks. In response to infection, all cattle produced early interferon type 1 in serum and, except for one calf, in nasal secretions. A finding not previously reported is the detection of interferon type 1 responses in bovine milk. All cattle developed high IgM antibody responses and long-lasting IgA antibody responses both systemically and locally. The serum IgM antibody responses came earlier in most of the calves than in the cows. Prolonged IgM antibody responses were detected in serum and milk, while those in nasal secretions were much shorter. BCV-specific IgA was present in nasal secretions from all cattle throughout the 6 months follow-up. The IgA antibody response in serum was detected up to 17 months post-infection and the duration showedan age-related variation indicating a more prominent IgA memory in the adult cattle and in the older calves than in the younger ones. BCV-specific IgG was detected in all cattle during the experimental period of up to 22 months. In conclusion, WD was reproduced in seronegative lactating cows. The cows showed severe general diseases than seronegative calves infected concurrently. Very long-lasting IgA antibody responses were detected both systemically and locally. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 16/07/20 alle ore 18:29:23