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Titolo:
Interferon alpha 2B and ribavirin in severe recurrent cholestatic hepatitis C
Autore:
Ong, JP; Younossi, ZM; Gramlich, T; Goodman, Z; Mayes, J; Sarbah, S; Yen-Lieberman, B;
Indirizzi:
Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA Inova Fairfax Hosp Falls Church VA USA 22042 , Falls Church, VA 22042 USA Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, OH 44195 USA Armed Forces Inst Pathol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA
Titolo Testata:
TRANSPLANTATION
fascicolo: 10, volume: 71, anno: 2001,
pagine: 1486 - 1488
SICI:
0041-1337(20010527)71:10<1486:IA2ARI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Younossi, ZM Inova Fairfax Hosp, Ctr Liver Dis, 3300 Gallows Rd, Falls Church, VA 22042USA Inova Fairfax Hosp 3300 Gallows Rd Falls Church VA USA 22042
Citazione:
J.P. Ong et al., "Interferon alpha 2B and ribavirin in severe recurrent cholestatic hepatitis C", TRANSPLANT, 71(10), 2001, pp. 1486-1488

Abstract

Severe recurrent cholestatic hepatitis C after Liver transplantation has apoor prognosis and no standard therapy is currently available. Four cases of severe recurrent cholestatic hepatitis C treated with a combination of interferon alpha 2b and ribavirin are described. All four patients were transplanted for hepatitis C-related cirrhosis. The mean age at transplantationwas 45 years (range 41-51 years). Three of the patients were male and one was female. Ah four patients had hepatitis C virus viremia before and afterliver transplantation. At 2 to 23 months after liver transplantation, all four patients developed jaundice, cholestatic elevation of Liver enzymes, and histopathology consistent with severe recurrent cholestatic hepatitis C. Combination of interferon and ribavirin was given with prompt virological suppression. Despite this rapid viral suppression, all four patients developed progressive graft failure with three deaths.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:44:59