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Titolo:
Lead intoxication during intrauterine life and lactation but not during adulthood reduces nucleus accumbens dopamine release as studied by brain microdialysis
Autore:
Devoto, P; Flore, G; Ibba, A; Fratta, W; Pani, L;
Indirizzi:
Univ Cagliari, Ctr Neuropharmacol, CNR, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 macol, CNR, I-09124 Cagliari, Italy Univ Cagliari, CNR, Ctr Neuropharmacol, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 t Neurosci, I-09124 Cagliari, Italy Univ Cagliari, Dept Publ Hlth, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 Publ Hlth, I-09124 Cagliari, Italy
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 3, volume: 121, anno: 2001,
pagine: 199 - 206
SICI:
0378-4274(20010519)121:3<199:LIDILA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-COURSE; TYROSINE-HYDROXYLASE; EXPOSURE; ATTAINMENT;
Keywords:
dopamine; intrauterine life; lead; nucleus accumbens; weaning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Pani, L Univ Cagliari, Ctr Neuropharmacol, CNR, Via Porcell 4, I-09124 Cagliari, Italy Univ Cagliari Via Porcell 4 Cagliari Italy I-09124 agliari, Italy
Citazione:
P. Devoto et al., "Lead intoxication during intrauterine life and lactation but not during adulthood reduces nucleus accumbens dopamine release as studied by brain microdialysis", TOX LETT, 121(3), 2001, pp. 199-206

Abstract

Environmentally relevant levels of lead (Pb) have been demonstrated to have a neurotoxic action, especially on children. In this study, Long-Evans rats were continuously exposed to Pb acetate in drinking water from early gestational days (2-6) or from 28 days of age. At the 13th week of age, the functional activity of the nucleus accumbens (NAC) dopaminergic system was studied by means of transversal microdialysis. Neither Pb treatment regimen modified dopamine (DA) and 3.3-dihydroxyphenylacetic acid (DOPAC) extracellular concentrations. with respect to control rats. However, neuronal depolarisation, induced by perfusion with 60 mM KCl, increased extracellular DA levels to a significantly minor degree in rats exposed to Pb during the intrauterine life. with respect to both control and adult Ph treated rats. The in utero treated rats also responded with a lower DA release to amphetamine(l mg,kg ip) administration. On the other hand. no difference in NAC DA level was found amongst treatment groups in response to different concentrations of the D,D, dopaminergic agonist quinpirole. locally administered by means of inverse dialysis. These data indicate a preferential impairment of NACDA synthesis acid/or release in rats exposed to Pb acetate during their intrauterine life. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:32:43