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Titolo:
Canines as sentinel species for assessing chronic exposures to air pollutants: Part 2. cardiac pathology
Autore:
Calderon-Garciduenas, L; Gambling, TM; Acuna, H; Garcia, R; Osnaya, N; Monroy, S; Villarreal-Calderon, A; Carson, J; Koren, HS; Devlin, RB;
Indirizzi:
US EPA, Human Studies Facil, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 xicol, Chapel Hill, NC 27599 USA Inst Nacl Pediat, Mexico City 14410, DF, Mexico Inst Nacl Pediat Mexico City DF Mexico 14410 exico City 14410, DF, Mexico Univ N Carolina, Ctr Environm Med & Lung Biol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Biol, Chapel Hill, NC 27599 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 61, anno: 2001,
pagine: 356 - 367
SICI:
1096-6080(200106)61:2<356:CASSFA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MAST-CELLS; MYOCARDIAL ISCHEMIA/REPERFUSION; ENDOTHELIAL-CELLS; HEART-DISEASE; MEXICO-CITY; INFLAMMATION; POLLUTION; ISCHEMIA; DEATH;
Keywords:
ambient air pollution; dogs; myocardium; mast cells; particulate matter; ozone; apoptotic myocytes and endothelial cells; endothelial injury; Mexico City;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Calderon-Garciduenas, L US EPA, Human Studies Facil, Natl Hlth & Environm Effects Res Lab, MD 58D,Res Triangle Pk, NC 27711 USA US EPA MD 58D Res Triangle Pk NC USA 27711 711 USA
Citazione:
L. Calderon-Garciduenas et al., "Canines as sentinel species for assessing chronic exposures to air pollutants: Part 2. cardiac pathology", TOXICOL SCI, 61(2), 2001, pp. 356-367

Abstract

The principal objective of this study is to evaluate by light and electronmicroscopy (LM, EM) the heart tissues in stray southwest and northeast metropolitan Mexico City (SWMMC, NEMMC) dogs and compare their findings to those from 3 less polluted cities (Cuernavaca, Tlaxcala, and Tuxpam), Clinically healthy mongrel dogs, including 109 from highly polluted SWMMC and NEMMC, and 43 dogs from less polluted cities were studied. Dogs residing in cities with lower levels of pollutants showed little or no cardiac abnormalities. Mexico City and Cuernavaca dogs exhibited LM myocardial alterations including apoptotic myocytes, endothelial and immune effector cells, degranulated mast cells associated with scattered foci of mononuclear cells in left and right ventricles and interventricular septum, and clusters of adipocytesinterspersed with mononuclear cells. Vascular changes included scattered polymorphonuclear leukocytes (PMN) margination and microthrombi in capillaries, and small venous and arteriolar blood vessels. Small veins exhibited smooth muscle cell hyperplasia, and arteriolar blood vessels showed deposition of particulate matter (PM) in the media and adventitia. Unmyelinated nerve fibers showed endoneural and epineural degranulated mast cells. EM examination of myocardial mast cells showed distended and abundant rough endoplasmic reticulum with few secretory granules. Myocardial capillaries exhibitedfibrin deposition and their endothelial cells displayed increased luminal and abluminal pinocytic activity and the formation of anemone-like protrusions of the endothelium into the lumen. A close association between myocardial findings, lung epithelial and endothelial pathology, and chronic inflammatory lung changes was noted. The myocardial changes described in dogs exposed to ambient air pollutants may form the basis for developing hypothesis-driven mechanistic studies that might explain the epidemiological data of increased cardiovascular morbidity and mortality in people exposed to air pollutants.

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Documento generato il 18/01/20 alle ore 13:02:03