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Titolo:
Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: Effects on long-term potentiation and [H-3]MK-801 binding in occipitalcortex and hippocampus
Autore:
Altmann, L; Mundy, WR; Ward, TR; Fastabend, A; Lilienthal, H;
Indirizzi:
Univ Dusseldorf, Med Inst Environm Hyg, Dept Neurobehav Toxicol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Dept Neurobehav Toxicol, D-40225 Dusseldorf, Germany Dept Neurobehav Toxicol Dusseldorf Germany D-40225 5 Dusseldorf, Germany Dept Analyt Chem, D-40225 Dusseldorf, Germany Dept Analyt Chem Dusseldorf Germany D-40225 D-40225 Dusseldorf, Germany US EPA, Div Neurotoxicol, Natl Hlth Environm Effectr Res Lab, Res TrianglePk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Res Lab, Res TrianglePk, NC 27711 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 61, anno: 2001,
pagine: 321 - 330
SICI:
1096-6080(200106)61:2<321:DEORTA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENER-SPECIFIC ANALYSIS; GYRUS IN-VIVO; POLYCHLORINATED-BIPHENYLS; VISUAL-CORTEX; DENTATE GYRUS; NMDA RECEPTORS; LEAD-EXPOSURE; SYNAPTIC TRANSMISSION; POSTNATAL EXPOSURE; MATERNAL EXPOSURE;
Keywords:
polychlorinated biphenyls; NMDA receptor; longterm potentiation; visual cortex; hippocampus; brain slices;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Altmann, L Univ Dusseldorf, Med Inst Environm Hyg, Dept Neurobehav Toxicol, Hennekamp50, D-40225 Dusseldorf, Germany Univ Dusseldorf Hennekamp 50 Dusseldorf Germany D-40225 ermany
Citazione:
L. Altmann et al., "Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: Effects on long-term potentiation and [H-3]MK-801 binding in occipitalcortex and hippocampus", TOXICOL SCI, 61(2), 2001, pp. 321-330

Abstract

The central nervous system is one of the target organs for polychlorinatedbiphenyls (PCBs), We measured the effects of maternal exposure of Long-Evans rats to a mixture of PCB congeners reconstituted according to the pattern found in human breast milk (reconstituted mixture, RM) on long-term potentiation (LTP) in two brain regions. Exposure of the dams via food started 50 days prior to mating and was terminated at birth, In the first experiment, adult male and female offspring were exposed maternally to 40 mg/kg of the RM or the commercial mixture Aroclor 1254 (A1254), LTP and paired-pulse inhibition were measured in slices of the visual cortex. In addition, the binding of [H-3]MK-801 to the N-methyl-D-aspartate (NMDA) receptor-ion channel as well as the [H-3]muscimol binding to the GABA-A receptor in membrane preparations from the occipital cortex and hippocampus were determined. LTP as well as [H-3]MK-801 binding were significantly reduced in the cortex following PCB exposure, while [H-3]MK-801 binding in the hippocampus was not affected. In a succeeding experiment, LTP was determined in cortical and hippocampal slices from rats at postnatal days 10 to 20, following exposure to0, 5, or 40 mg/kg of the RM, Cortical LTP was significantly affected by the RM while no effects were seen in hippocampal LTP, Taking the two experiments together, PCB exposure significantly reduced LTP, as well as [H-3]MK-801 binding, in the cortex and had no effect in the hippocampus. The LTP deficits can only partly be related to the reduction of binding sites to the NMDA receptor; other PCB-induced neurochemical changes have to be assumed.

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Documento generato il 10/04/20 alle ore 02:37:16