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Titolo:
Thymoma and lupus: two cases and a literature review.
Autore:
Genty, I; Jean, R; Cretel, E; Xeridat, B; Astoul, P; Poulain, P; Lefevre, P; Gastaut, JA; Durand, JM;
Indirizzi:
Hop St Marguerite, Serv Med Interne, F-13274 Marseille 9, France Hop St Marguerite Marseille France 9 nterne, F-13274 Marseille 9, France
Titolo Testata:
REVUE DE MEDECINE INTERNE
fascicolo: 5, volume: 22, anno: 2001,
pagine: 475 - 484
SICI:
0248-8663(200105)22:5<475:TALTCA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
FRE
Soggetto:
MYASTHENIA-GRAVIS; MALIGNANT THYMOMA; ERYTHEMATOSUS; THYMECTOMY; DISEASES; PATIENT;
Keywords:
lupus; thymoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Durand, JM Hop St Marguerite, Serv Med Interne, 270 Blvd St Marguerite, F-13274 Marseille 9, France Hop St Marguerite 270 Blvd St Marguerite Marseille France 9 ce
Citazione:
I. Genty et al., "Thymoma and lupus: two cases and a literature review.", REV MED IN, 22(5), 2001, pp. 475-484

Abstract

Introduction. - Thymoma is a tumour originating in the epithelial cells ofthe thymus, associated with several immunologic disorders. The associationof thymoma with systemic lupus erythematosus has rarely been described. Wereport two cases of this association. Exegesis. - Description of two cases and a review of the literature. Mr T:was 41 years old when the diagnosis of thymoma and lupus was made. The thymectomy did not influence the evolution of his lupus. Mrs G. had been treated because of a lupus for 8 years prior to developing a thymoma. One year later she presented with erythroblastopenia, which was only sensitive to cyclosporin. Conclusion. - The association between lupus and thymoma has been reported in 36 cases in the literature. Thymoma is benign in 59% of the cases. The clinical presentation of lupus is nonspecific except for age, median 48 years, and sex ratio, 4:3. The clinical outcome of the lupus is not influenced by the thymectomy. Thymoma may precede lupus with a delay of several years or it may be diagnosed concurrently or several years later. This association is not accidental, though the pathogenic link between these conditions remains unknown. One could suppose that the decrease of the thymic function in the course of thymoma could enhance the expression of autoreactive T lymphocytes as well as the activation of B cells. Patients should be followed after thymectomy because autoimmune diseases, particularly lupus, may develop belatedly. On the other hand, thymoma may be suspected mainly when lupus occurs in patients around 50 years of age. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:51:21