Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTERFERON IMMUNOGENICITY - PRECLINICAL EVALUATION OF INTERFERON-ALPHA-2A
Autore:
PALLERONI AV; AGLIONE A; LABOW M; BRUNDA MJ; PESTKA S; SINIGAGLIA F; GAROTTA G; ALSENZ J; BRAUN A;
Indirizzi:
HOFFMANN LA ROCHE INC,DEPT ONCOL,340 KINGSLAND ST NUTLEY NJ 07110 HOFFMANN LA ROCHE INC,DEPT ONCOL NUTLEY NJ 07110 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT MOL GENET& MICROBIOL PISCATAWAY NJ 08854 ROCHE MILANO RIC NEW BRUNSWICK NJ 00000 F HOFFMANN LA ROCHE & CO LTD CH-4002 BASEL SWITZERLAND HOFFMANN LA ROCHE INC,INFLAMMAT AUTOIMMUNE DIS NUTLEY NJ 07110 CANC INST NEW JERSEY NEW BRUNSWICK NJ 00000
Titolo Testata:
Journal of interferon & cytokine research
, volume: 17, anno: 1997, supplemento:, 1
pagine: 23 - 27
SICI:
1079-9907(1997)17:<23:II-PEO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIRY-CELL LEUKEMIA; NEUTRALIZING ANTIBODIES; CLINICAL-SIGNIFICANCE; ALPHA-INTERFERON; HIGHER OLIGOMERS; GENOMIC DNA; VARIANTS; THERAPY; DIMERS; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Palleroni et al., "INTERFERON IMMUNOGENICITY - PRECLINICAL EVALUATION OF INTERFERON-ALPHA-2A", Journal of interferon & cytokine research, 17, 1997, pp. 23-27

Abstract

A preclinical evaluation of the immunogenicity of various preparations of interferon-a (IFN-cu) was performed with in vitro and in vivo animal models, The distribution of genes for IFN-alpha 2a, IFN-alpha 2b, and IFN-alpha 2c in various cell populations and the response of humanT cell clones to IFN-alpha peptides were investigated, The immunogenicity of IFN-alpha in IFN-alpha 2b transgenic mice and factors that influence the immunogenicity of IFN-cu in normal mice were also studied, The genes for IFN-alpha 2a and IFN-alpha 2b were found in KG-1 cells, whereas IFN-alpha 2b and IFN-alpha 2c genes were present in Namalwa cells, No difference in proliferation of human T cells, T cell lines, orT cell clones could be obtained with IFN-alpha peptides, In transgenic mice bearing the human IFN-alpha 2b gene, no antibody response was obtained following immunization with either IFN-alpha 2a or IFN-alpha 2b, Normal mice immunized with either IFN-alpha 2a or IFN-alpha 2b produced equivalent titers of antibodies, which cross-reacted with both IFNs. Studies evaluating the relative immunogenicity of IFN-alpha in normal mice demonstrated that a number of treatment and host variables can modulate immunogenicity of IFN-alpha preparations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:11:34