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Titolo:
Behavioral analysis indicates benzodiazepine-tolerance mediated by the benzodiazepine binding-site at the GABA(A)-receptor
Autore:
Schmitt, U; Luddens, H; Hiemke, C;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 , Dept Psychiat, D-55101 Mainz, Germany
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 1145 - 1160
SICI:
0278-5846(200107)25:5<1145:BAIBMB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; ANTICONVULSANT CROSS-TOLERANCE; GAMMA-AMINOBUTYRIC-ACID; AMYGDALA-KINDLED RATS; GABA-TRANSPORTER; RECEPTOR-BINDING; DIAZEPAM TREATMENT; HYPNOTIC DRUGS; OPEN-FIELD; LORAZEPAM;
Keywords:
diazepam; elevated plus-maze; GABA(A)-receptor; GAT; open-field; SKF-89976A; tolerance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitt, U Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55101 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55101 rmany
Citazione:
U. Schmitt et al., "Behavioral analysis indicates benzodiazepine-tolerance mediated by the benzodiazepine binding-site at the GABA(A)-receptor", PROG NEUR-P, 25(5), 2001, pp. 1145-1160

Abstract

1. GABA(A)-receptor induced changes in locomotion and anxiety-like behaviors were studied in rats using an open-field and an elevated plus-maze. Acute and chronic doses of the benzodiazepine diazepam without and in combination with the GABA uptake inhibitor SKF-89976A were investigated.2. Fifty-six male rats of the strain PVG/OlaHsd (PVG; 180-200g body wt) were used to assess the influence of the benzodiazepine binding-site to the development of tolerance. Rats were divided into six groups: The first receiving saline (0.9%), the second and third diazepam (10.0 mg/kg) daily for 23days with or without an acute challenge of 2.0 mg/kg diazepam. The fourth group received diazepam (10.0 mg/kg) daily and acutely SKF-89976A (15.0 mg/kg) plus diazepam and the fifth and sixth group received acute treatment with diazepam (2.0 mg/kg) or SKF-89976A (15.0 mg/kg).3. Under chronic treatment with diazepam the animals became tolerant to acute doses of diazepam in activity and anxiety-related behaviors. Acute treatment with SKF-89976A increased exploration. Parameters expressing anxiolytic-like behaviors were increased, too, but not all of them significantly. In diazepam tolerant animals SKF-89976A produced anxiolytic-like behaviors4. We conclude that the BZ- and not the GABA-binding site at the GABA(A)-receptor is involved in the development of BZ-tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:59:21