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Titolo:
Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice
Autore:
Rilke, O; Will, K; Jahkel, M; Oehler, J;
Indirizzi:
Tech Univ Dresden, Klin & Poliklin Psychiat & Psychotherapie, AG Neurobiol, Dresden, Germany Tech Univ Dresden Dresden Germany rapie, AG Neurobiol, Dresden, Germany
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 1125 - 1144
SICI:
0278-5846(200107)25:5<1125:BANEOA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOLATION-INDUCED AGGRESSION; IN-VIVO MICRODIALYSIS; HIGH-ACTIVE MICE; DOPAMINE RELEASE; SEROTONIN LEVELS; SOCIAL-ISOLATION; PSYCHOTROPIC-DRUGS; 5-HT1B RECEPTOR; FLUOXETINE; BRAIN;
Keywords:
aggressive behavior; anpirtoline; citalopram; dopamine metabolism; principal component factor analysis; serotonin metabolism; social isolation; SSRI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Rilke, O AG Neurobiol, Psychiat Klin, Fetscherstr 74, D-01307 Dresden, Germany AG Neurobiol Fetscherstr 74 Dresden Germany D-01307 den, Germany
Citazione:
O. Rilke et al., "Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice", PROG NEUR-P, 25(5), 2001, pp. 1125-1144

Abstract

1. Acute effects of serotonergic drugs acting via different mechanisms were investigated by a social interaction test and subsequent determination ofserotonin and dopamine metabolisms in mice housed in groups or isolated for G weeks.2. A resident / intruder test was performed with anpirtoline (5-HT1B receptor agonist in rodents; 1 mg/kg), citalopram (SSRI; 0.5 mg/kg) and saline treatment before animals were decapitated and different brain regions were frozen for subsequent HPLC-analyses.3. Behavioral investigations indicated a strong increase of aggressive behavior after 6 weeks of isolation housing. Acute citalopram treatment did not influence behavioral parameters of isolated and group housed mice. In contrast, anpirtoline antagonized isolation induced aggressive behavioral components in a specific manner.4. Analysis of dopamine and serotonin metabolism revealed that citalopram treatment did not affect dopamine metabolism, but reduced serotonin metabolism in the striatum, hippocampus, cortex and midbrain independent of housing conditions.5. In contrast, anpirtoline treatment increased dopamine metabolism in cortex, striatum and midbrain as well as influenced serotonin metabolism in a structure- and state-specific manner. Whereas anpirtoline decreased serotonin metabolism in the cortex, the midbrain and the hippocampus independent of housing conditions, in the striatum anpirtoline abolished the isolation induced decrease of serotonin metabolism.6. These results indicate that anpirtoline might induce antiaggressive effects via postsynaptic receptor- and structure- specific activation of serotonergic but also dopaminergic processes, whereas structure independent increase of synaptic serotonin via citalopram was ineffective to reverse aggressivity in isolated mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:02:42