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Titolo:
Platelet serotonin concentrations in medicated schizophrenic patients
Autore:
Kaneda, Y; Fujii, A; Nagamine, I;
Indirizzi:
Univ Tokushima, Sch Med, Dept Neuropsychiat, Tokushima 7708503, Japan UnivTokushima Tokushima Japan 7708503 sychiat, Tokushima 7708503, Japan Fujii Hosp, Dept Neuropsychiat, Tokushima, Japan Fujii Hosp Tokushima Japan i Hosp, Dept Neuropsychiat, Tokushima, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 983 - 992
SICI:
0278-5846(200107)25:5<983:PSCIMS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS;
Keywords:
extrapyramidal symptoms; monoamine oxidase; neuroleptics; psychopathology; schizophrenia; serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneda, Y Univ Tokushima, Sch Med, Dept Neuropsychiat, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708503 pan
Citazione:
Y. Kaneda et al., "Platelet serotonin concentrations in medicated schizophrenic patients", PROG NEUR-P, 25(5), 2001, pp. 983-992

Abstract

1. The present study was conducted to investigate the effects of neuroleptic administration on platelet serotonin (5-HT) levels, and the relationships between platelet 5-HT levels, extrapyramidal symptoms (EPS) and psychopathology in schizophrenia.2. The subjects were 49 regularly medicated inpatients who were diagnosed according to the DSM-IV criteria for schizophrenia. Each patient gave informed consent for the research involved in this study. All patients were first considered as one group and then divided into two groups: those with lower levels (LL) and those with higher levels (HL), according to their platelet 5-HT levels. Psychotic symptoms and EPS were assessed using the Brief Psychiatric Rating Scale and the Drug Induced Extra-Pyramidal Symptoms Scale, respectively.3. (1) The mean level of the platelet 5-HT in the schizophrenics with neuroleptic-treatment was significantly lower than that in the normal subjects. (2) The mean level of the blood monoamine oxidase (MAO) in the schizophrenics tended to be lower than that in the normal subjects. (3) There was no significant difference in the mean scores of the positive symptoms, negativesymptoms, or EPS between the LL and HL groups. (4) Platelet 5-HT levels were not correlated with blood MAO concentrations.4. Overall, these results seem to indicate that (i) administration of neuroleptics lowers platelet 5-HT levels, and (ii) platelet 5-HT levels in the schizophrenics with neuroleptic-treatment do not reflect psychopathology ofschizophrenia or severity of neuroleptic-induced EPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:04:17