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Titolo:
Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy
Autore:
Fehr, C; Schleicher, A; Szegedi, A; Anghelescu, I; Klawe, C; Hiemke, C; Dahmen, N;
Indirizzi:
Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 nz, Dept Psychiat, D-6500 Mainz, Germany
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 965 - 982
SICI:
0278-5846(200107)25:5<965:SPIPSF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPTOPHAN-HYDROXYLASE GENE; BIPOLAR AFFECTIVE-DISORDER; 5-HT2A RECEPTOR GENE; SEASONAL AFFECTIVE-DISORDER; T102C POLYMORPHISM; SUICIDAL-BEHAVIOR; NO ASSOCIATION; ALLELIC ASSOCIATION; DEPRESSED-PATIENTS; PANIC DISORDER;
Keywords:
alcoholism genetics; anxiety disorders; 5-HTR2A; narcolepsy genetics; psychiatric genetics; serotonin; tryptophan hydroxylase polymorphism;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Fehr, C Vet Affairs Med Ctr, Res Serv R&D 40, 3710 SW US Vet Rd, Portland,OR 97201 USA Vet Affairs Med Ctr 3710 SW US Vet Rd Portland OR USA 97201 01 USA
Citazione:
C. Fehr et al., "Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy", PROG NEUR-P, 25(5), 2001, pp. 965-982

Abstract

1. Alterations in the serotonergic neurotransmission have been frequently described for patients suffering from alcoholism, anxiety disorders and narcolepsy.2. The authors tested for association of the 5-HT2A receptor polymorphism (T102C) and the intron 7 tryptophan hydroxylase (TPH) polymorphism (A218C) among 176 alcohol dependent patients, 35 patients with panic disorder, 50 patients with generalized anxiety disorder, 55 patients with narcolepsy and 87 healthy controls.3. Allele and genotype frequencies of the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH polymorphism (A218C) were almost similar between thepatients suffering from alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy.4. There was no association between the 5-HT2A receptor polymorphism (T102C), the intron7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of Germanpatients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:54:11