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Titolo:
The role of leptin in the transition from fetus to neonate
Autore:
Mostyn, A; Keisler, DH; Webb, R; Stephenson, T; Symonds, ME;
Indirizzi:
Univ Nottingham Hosp, Sch Human Dev, Acad Div Child Hlth, Nottingham NG7 2UH, England Univ Nottingham Hosp Nottingham England NG7 2UH tingham NG7 2UH, England Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Anim Sci, Columbia, MO 65211 USA Univ Nottingham, Sch Biosci, Div Agr & Hort, Loughborough LE12 5RD, Leics,England Univ Nottingham Loughborough Leics England LE12 5RD 12 5RD, Leics,England
Titolo Testata:
PROCEEDINGS OF THE NUTRITION SOCIETY
fascicolo: 2, volume: 60, anno: 2001,
pagine: 187 - 194
SICI:
0029-6651(200105)60:2<187:TROLIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; RECEPTOR MESSENGER-RNA; PROTEIN-3 GENE-EXPRESSION; IN-SITU HYBRIDIZATION; CORD-BLOOD LEPTIN; BODY-MASS INDEX; UNCOUPLING PROTEIN; SKELETAL-MUSCLE; PLASMA LEPTIN; OBESE GENE;
Keywords:
leptin; brown adipose tissue; neonate; uncoupling protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Mostyn, A Univ Nottingham Hosp, Sch Human Dev, Acad Div Child Hlth, Nottingham NG7 2UH, England Univ Nottingham Hosp Nottingham England NG7 2UH 7 2UH, England
Citazione:
A. Mostyn et al., "The role of leptin in the transition from fetus to neonate", P NUTR SOC, 60(2), 2001, pp. 187-194

Abstract

Leptin is a 16 kDa hormone which has been shown to have a major physiological role in the control of energy balance. Leptin is produced primarily in white adipose tissue, although there is evidence for its production in brown adipose tissue (BAT) and the placenta. BAT is critically important for the initiation of non-shivering thermogenesis in the newborn through the BAT-specific uncoupling protein (UCP), UCP1. This factor is particularly important in lambs in which levels of UCP1 peak at birth, concomitant with a rapid decline in plasma leptin levels. Our studies have examined the effect of acute and chronic administration of leptin to neonatal lambs, investigatingeffects on colonic temperature, UCP1 and thermogenic potential of BAT. Administration of leptin in sequential physiological doses of 10, 100 and 100 mug to neonatal lambs caused a modest increase in colonic temperature whichwas not observed in weight-matched vehicle-treated controls. This increasein colonic temperature was not mediated by an increase in either abundanceor thermogenic potential of UCP1, as previously shown in adult rodents. UCP1 mRNA levels were 30 % lower in leptin-treated lambs, which is also contradictory to findings in adult rodents. Leptin treatment resulted in a dose-dependent rise in plasma leptin, with levels at the end of the study being almost twenty times greater in leptin-treated animals. To determine whetherthese findings in neonatal lambs were transient due to the complex milieu of hormones present after birth, we examined the effect of chronic leptin treatment over 6 d. Pairs of lambs were treated daily, from the second to seventh day of life with 100 mug leptin or vehicle. Colonic temperatures of leptin- and vehicle-treated animals remained similar throughout the study. UCP1 abundance was significantly lower in the leptin-treated animals, suggesting that the drop in UCP1 mRNA seen in the previous study had been translated to protein levels. In conclusion, the decline in plasma leptin levels at birth may be a signal to initiate enteral feeding. In lambs, the rapid loss of UCP1 mRNA, which occurs within the first few days of life, appears tobe accelerated by leptin administration, possibly stimulating the development of white adipose tissue and generation of body heat through mechanisms other than non-shivering thermogenesis by UCP1 in BAT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:43:03