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Titolo:
Time resolved collapse of a folding protein observed with small angle x-ray scattering
Autore:
Pollack, L; Tate, MW; Finnefrock, AC; Kalidas, C; Trotter, S; Darnton, NC; Lurio, L; Austin, RH; Batt, CA; Gruner, SM; Mochrie, SGJ;
Indirizzi:
Cornell Univ, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 lid State Phys Lab, Ithaca, NY 14853 USA Cornell Univ, Nanobiotechnol Ctr, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Nanobiotechnol Ctr, Ithaca, NY 14853 USA Princeton Univ, Dept Phys, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 Dept Phys, Princeton, NJ 08544 USA MIT, Dept Phys, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Phys, Cambridge, MA 02139 USA
Titolo Testata:
PHYSICAL REVIEW LETTERS
fascicolo: 21, volume: 86, anno: 2001,
pagine: 4962 - 4965
SICI:
0031-9007(20010521)86:21<4962:TRCOAF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-DOMAIN PROTEINS; BETA-LACTOGLOBULIN; KINETICS; STATE; MECHANISM; PATHWAYS; RATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
--discip_EC--
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Pollack, L Cornell Univ, Atom & Solid State Phys Lab, Ithaca, NY 14853 USACornell Univ Ithaca NY USA 14853 hys Lab, Ithaca, NY 14853 USA
Citazione:
L. Pollack et al., "Time resolved collapse of a folding protein observed with small angle x-ray scattering", PHYS REV L, 86(21), 2001, pp. 4962-4965

Abstract

High-intensity, "pink" beam from an undulator was used in conjunction withmicrofabricated rapid-fluid mixing devices to monitor the early events in protein folding with time resolved small angle x-ray scattering. This Letter describes recent work on the protein bovine P-lactoglobulin where collapse from an expanded to a compact set of states was directly observed on the millisecond time scale. The role of chain collapse, one of the initial stages of protein folding, is not currently understood. The characterization oftransient, compact states is vital in assessing the validity of theories and models of the Folding process.

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Documento generato il 27/09/20 alle ore 06:05:10