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Titolo:
Evaluation of carboxymethylpullulan as a novel carrier for targeting immune tissues
Autore:
Masuda, K; Sakagami, M; Horie, K; Nogusa, H; Hamana, H; Hirano, K;
Indirizzi:
Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 5530002, Japan Shionogi & Co Ltd Osaka Japan 5530002 Fukushima Ku, Osaka 5530002, Japan
Titolo Testata:
PHARMACEUTICAL RESEARCH
fascicolo: 2, volume: 18, anno: 2001,
pagine: 217 - 223
SICI:
0724-8741(200102)18:2<217:EOCAAN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; ACCUMULATION; DISPOSITION; CONJUGATE; DEXTRAN;
Keywords:
carboxymethylpullulan; targeting; immune tissues; immunosuppressant; conjugate; adjuvant arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Masuda, K Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, 5-12-4 Sagisu, Osaka 5530002, Japan Shionogi & Co Ltd 5-12-4 Sagisu Osaka Japan 5530002 0002, Japan
Citazione:
K. Masuda et al., "Evaluation of carboxymethylpullulan as a novel carrier for targeting immune tissues", PHARM RES, 18(2), 2001, pp. 217-223

Abstract

Purpose. To demonstrate the potential of carboxymethylpullulan (CMPul) as a carrier for targeting immune tissues, and to find whether immune tissues could be set as the target of an immunosuppressant to treat autoimmune diseases. Methods. The biodistribution of CMPul was investigated to evaluate its potency as a carrier for targeting immune tissues. Furthermore, an immunosuppressant-CMPul conjugate was prepared and its suppressive effect on rat adjuvant arthritis was examined. Results. The disappearance rate of H-3-labeled CMPul from the blood circulation was much slower than that of H-3-labeled pullulan (Pul) after intravenous injection to normal rats. The concentration of H-3-labeled CMPul in the spleen and lymph nodes was much higher than that of H-3-labeled Pul at 24hours after the injection, whereas the concentration of H-3-labeled CMPul in the liver was significantly lower than that of H-3-labeled Pul. A similar targeting property of H-3-labeled CMPul for these immune tissues was observed in arthritic rats. A conjugate composed of a novel immunosuppressant PA-48153C and CMPul showed a suppressive effect on rat adjuvant arthritis judging from a reduction of the arthritic index and spleen weight and an increase of body weight. Conclusions. CMPul is expected to be a promising carrier for targeting immune tissues with an immunosuppressant to enable treatment of autoimmune diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:37:41